US2022023203A1PendingUtilityA1

Method for manufacturing medicated chewing gum without cooling

66
Assignee: PER OS BIOSCIENCES LLCPriority: Jun 5, 2014Filed: Oct 12, 2021Published: Jan 27, 2022
Est. expiryJun 5, 2034(~7.8 yrs left)· nominal 20-yr term from priority
Inventors:Lisa BachmannRobert Estey
A61K 36/3482A61K 31/658A23G 4/10A23G 4/068A61K 31/522A23G 4/18A61K 31/722A23V 2002/00A23G 4/12A23G 4/08A61K 9/0058A23G 4/066A61K 31/05A61K 36/185A61K 47/26
66
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Claims

Abstract

An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.

Claims

exact text as granted — not AI-modified
1 - 24 . (canceled) 
     
     
         25 . A composition comprising: a sugar alcohol, a blend of sugar alcohols, a sugar or blend of sugars, a gum base, flavoring, one or more active ingredients, tableting lubricants, powder flow agents, sweeteners and combinations thereof. 
     
     
         26 . The composition of  claim 25 , wherein the composition comprises:
 a sugar alcohol or a blend of sugar alcohols, a sugar, a blend of sugars and combinations thereof, from about 20% to about 90% by weight of the total weight of the composition;   a gum base from about 10% to about 60% by weight of the total weight of the composition;   a flavoring from about 0.1% to about 30% by weight of the total weight of the composition;   a tableting lubricant and/or powder flow agents from about 0.1% to about 20% by weight of the total weight of the composition;   an intensive sweetner(s) from about 0.01% to about 15% by weight of the total weight of the composition;   an active ingredient from about 0.01% to about 40% by weight of the total weight of the composition; and,   combinations thereof.   
     
     
         27 . The composition of  claim 26 , wherein the composition comprises:
 a sugar alcohol, a blend of sugar alcohols, a sugar, a blend of sugars and combinations thereof, from about 40% to about 85% by weight of the total weight of the composition;   a gum base from about 15% to about 35% by weight of the total weight of the composition;   a flavoring from about 1% to about 25% by weight of the total weight of the composition;   a tableting lubricant and/or powder flow agents from about 1% to about 10% by weight of the total weight of the composition;   an intensive sweetner(s) from about 0.1% to about 10% by weight of the total weight of the composition;   an active ingredient from about 1% to about 30% by weight of the total weight of the composition; and,   combinations thereof.   
     
     
         28 . The composition of  claim 27 , wherein the composition comprises:
 a sugar alcohol, a blend of sugar alcohols, a sugar, a blend of sugars and combinations thereof, from about 40% to about 80% by weight of the total weight of the composition;   a gum base from about 15% to about 40% by weight of the total weight of the composition;   a flavoring from about 1% to about 20% by weight of the total weight of the composition;   a tableting lubricant and/or powder flow agents from about 0.5% to about 15% by weight of the total weight of the composition;   an intensive sweetner(s) from about 0.1% to about 5% by weight of the total weight of the composition;   an active ingredient from about 0.5% to about 30% by weight of the total weight of the composition; and,   combinations thereof.   
     
     
         29 . The composition of  claim 25 , wherein the active ingredient is chitosan, caffeine, cannabidiol (CBD) or hemp oil. 
     
     
         30 . The composition of  claim 25 , wherein the sugar alcohol or the blend of sugar alcohols comprise sorbitol, isomalt, xylitol, maltitol, mannitol, erythritol and combinations thereof. 
     
     
         31 . The composition of  claim 25 , wherein the sugar or the blend of sugars comprises: dextrose, sucrose, fructose, glucose and combinations thereof. 
     
     
         32 . The composition of  claim 25 , further comprising: microcrystalline cellulose, dextrose, modified starch, starch derivatives or other liquidsolid systems. 
     
     
         33 . A composition comprising: a sugar alcohol, a blend of sugar alcohols, a sugar or blend of sugars, a gum base, flavoring, one or more active ingredients, tableting lubricants, powder flow agents, sweeteners, microcrystalline cellulose, dextrose, modified starch, starch derivatives or other liquidsolid system, and combinations thereof. 
     
     
         34 . The composition of  claim 33 , wherein the composition comprises:
 a sugar alcohol or a blend of sugar alcohols, microcrystalline cellulose, dextrose, modified starch, starch derivatives or other liquidsolid system, and combinations thereof from about 20% to about 80% by weight of the total weight of the composition;   a gum base from about 10% to about 60% by weight of the total weight of the composition;   a flavoring from about 1% to about 30% by weight of the total weight of the composition;   a tableting lubricant and/or powder flow agents from about 0.1% to about 20% by weight of the total weight of the composition;   an intensive sweetner(s) from about 0.01% to about 10% by weight of the total weight of the composition;   an active ingredient from about 0.01% to about 40% by weight of the total weight of the composition; and,   combinations thereof.   
     
     
         35 . The composition of  claim 34 , wherein the composition comprises:
 a sugar alcohol, a blend of sugar alcohols, a sugar, a blend of sugars, microcrystalline cellulose, dextrose, modified starch, starch derivatives or other liquidsolid system, and combinations thereof, from about 40% to about 85% by weight of the total weight of the composition;   a gum base from about 15% to about 55% by weight of the total weight of the composition;   a flavoring from about 1% to about 25% by weight of the total weight of the composition;   a tableting lubricant and/or powder flow agents from about 1% to about 10% by weight of the total weight of the composition;   an intensive sweetner(s) from about 0.1% to about 10% by weight of the total weight of the composition;   an active ingredient from about 1% to about 30% by weight of the total weight of the composition; and,   combinations thereof.   
     
     
         36 . The composition of  claim 35 , wherein the composition comprises:
 a sugar alcohol, a blend of sugar alcohols, a sugar, a blend of sugars, microcrystalline cellulose, dextrose, modified starch, starch derivatives or other liquidsolid system, and combinations thereof, from about 40% to about 75% by weight of the total weight of the composition;   a gum base from about 15% to about 50% by weight of the total weight of the composition;   a flavoring from about 1% to about 15% by weight of the total weight of the composition;   a tableting lubricant and/or powder flow agents from about 0.5% to about 15% by weight of the total weight of the composition;   an intensive sweetner(s) from about 0.5% to about 7.5% by weight of the total weight of the composition;   an active ingredient from about 0.5% to about 20% by weight of the total weight of the composition; and,   combinations thereof.   
     
     
         37 . The composition of  claim 33 , wherein the active ingredient is cannabidiol (CBD) or hemp oil.

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