Method and system to optimize pharmacotherapy

Abstract

A method of optimizing pharmacotherapy includes monitoring one or more characteristics of a patient associated with a condition of the patient and evaluating a baseline severity of the condition of the patient, recommending a selected therapy to the patient based on a therapy efficacy-risk map, evaluating an actual severity of the condition of the patient, evaluating an efficacy of the selected therapy, evaluating a risk score of the selected therapy, and updating the therapy efficacy-risk map based on the evaluated efficacy and risk score of the selected therapy.

What is claimed is: 
     
         1 . A method of optimizing pharmacotherapy, the method comprising:
 monitoring one or more characteristics of a patient associated with a condition of the patient and evaluating a baseline severity of the condition of the patient;   recommending a selected therapy to the patient based on a therapy efficacy-risk map;   evaluating an actual severity of the condition of the patient;   evaluating an efficacy of the selected therapy;   evaluating a risk score of the selected therapy; and   updating the therapy efficacy-risk map based on the evaluated efficacy and risk score of the selected therapy.   
     
     
         2 . The method of  claim 1 , wherein the therapy efficacy-risk map corresponds one or more therapies with one or more levels of severity of the condition and includes efficacies and risk scores of the one or more therapies, and wherein recommending the selected therapy includes selecting a therapy from the therapy efficacy-risk map corresponding to the severity of the condition of the patient which maximizes efficacy and minimizes risk among the therapies corresponding to the severity of the condition of the patient. 
     
     
         3 . The method of  claim 2 , wherein updating the therapy efficacy-risk map includes replacing the efficacy associated with the selected therapy with the evaluated efficacy and replacing the risk score associated with the selected therapy with the evaluated risk score. 
     
     
         4 . The method of  claim 2 , wherein the therapy efficacy-risk map is a default map based on population data, and wherein updating the therapy efficacy-risk map includes replacing the efficacy and risk score associated in the default therapy efficacy-risk map with the selected therapy with the evaluated efficacy and evaluated risk score. 
     
     
         5 . The method of  claim 2 , wherein the therapy that maximizes efficacy and minimizes risk is determined using a composite cost function. 
     
     
         6 . The method of  claim 1 , wherein evaluating the efficacy of the therapy is based on one or more of a comparison of the predicted severity of the condition to the actual severity of the condition, a sleep quality score, and an alertness score. 
     
     
         7 . The method of  claim 6 , wherein evaluating the efficacy of the therapy is based on a comparison of the baseline severity of the condition to the actual severity of the condition, a sleep quality score, and an alertness score, and wherein each of the comparison of the baseline severity of the condition to the actual severity of the condition, the sleep quality score, and the alertness score has an associated weighting. 
     
     
         8 . The method of  claim 1 , wherein monitoring one or more of the characteristics of the patient includes monitoring one or more objective physiological characteristics associated with Restless Legs Syndrome (RLS), and wherein evaluating the actual severity of the condition is based on the one or more objective physiological characteristics. 
     
     
         9 . The method of  claim 1 , wherein monitoring one or more characteristics of the patient includes monitoring one or more of side effects, augmentation metrics, and stressors, and wherein evaluating the risk score of the selected therapy is based on one or more of the monitored side effects, augmentation metrics, and stressors. 
     
     
         10 . The method of  claim 9 , wherein the side effects are monitored using subjective inputs from the patient and natural language processing of subjective inputs. 
     
     
         11 . The method of  claim 1 , recommending the selected therapy to the patient includes determining a risk score associated with a current therapy of the patient and selecting the current therapy of the patient if the risk score associated with the current therapy is below a risk score threshold. 
     
     
         12 . The method of  claim 1 , wherein the selected therapy includes a drug type, a dosage, and a dose time. 
     
     
         13 . The method of  claim 1 , wherein the condition is RLS. 
     
     
         14 . A system for optimizing pharmacotherapy, the system comprising:
 one or more sensing modules structured to monitor one or more characteristics of a patient associated with a condition of the patient;   a baseline severity module structured to determine a severity of the condition of the patient;   a selected therapy module structured to store a recommended therapy to the patient based on a therapy efficacy-risk map;   an actual severity evaluation module structured to evaluate an actual severity of the condition of the patient;   a therapy efficacy evaluation module structured to evaluate an efficacy of the recommended therapy;   a risk evaluation module structured to evaluate a risk score of the recommended therapy; and   a therapy efficacy-risk map update module structured to update the therapy efficacy-risk map based on the evaluated efficacy and risk score of the recommended therapy.   
     
     
         15 . A non-transitory computer readable medium storing one or more programs, including instructions, which when executed by a computer, causes the computer to perform a method of optimizing pharmacotherapy, the method comprising:
 monitoring one or more characteristics of a patient associated with a condition of the patient and evaluating a baseline severity of the condition of the patient;   recommending a selected therapy to the patient based on a therapy efficacy-risk map;   evaluating an actual severity of the condition of the patient;   evaluating an efficacy of the selected therapy;   evaluating a risk score of the selected therapy; and   updating the therapy efficacy-risk map based on the evaluated efficacy and risk score of the selected therapy.