Methods and compositions to graft bone using iron excipients

Abstract

A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.

1 . A bone graft composition comprising a calcium phosphate putty and at least one of the following: a hardening agent, an agent that controls the rate of curing, an acidifying agent, an iron excipient, collagen, and a diluent solution. 
     
     
         2 . The bone graft composition of  claim 1 , wherein the calcium phosphate putty comprises biphasic calcium phosphate particles. 
     
     
         3 . The bone graft composition of  claim 2 , wherein the biphasic calcium phosphate particles comprise hydroxyapatite and tricalcium phosphate. 
     
     
         4 . The bone graft composition of  claim 3 , wherein the biphasic calcium phosphate particles comprise about 20-60% hydroxyapatite and about 40-80% tricalcium phosphate. 
     
     
         5 . The bone graft composition of  claim 1 , further comprising an active agent. 
     
     
         6 . The bone graft composition of  claim 5 , wherein the active agent is delivered at a controlled rate. 
     
     
         7 . The bone graft composition of  claim 6 , wherein the active agent is selected from the group consisting of naloxone, naltrexone, and a salt thereof. 
     
     
         8 . A method of repairing a bone defect in a patient in need thereof, comprising applying a bone graft composition to the bone defect, wherein the bone graft composition comprises a calcium phosphate putty, an acidifying agent and at least one of the following: a hardening agent, an agent that controls the rate of curing, an iron excipient, collagen, and a diluent solution. 
     
     
         9 . The method of  claim 8 , wherein the bone defect is caused by a human disease or condition, and wherein the bone graft composition comprises an active agent for treating the human disease or condition. 
     
     
         10 . The method of  claim 8 , wherein the bone defect is caused by a human disease or condition, and wherein the bone graft composition does not contain an active agent for treating the human disease or condition. 
     
     
         11 . The method of  claim 9 , wherein the human disease or condition is a cancer. 
     
     
         12 . The method of  claim 9 , wherein the human disease or condition is one of several disorders of the spinal vertebral bones that requires surgical intervention to fuse the vertebral bones together. 
     
     
         13 . The method of  claim 9 , wherein the human disease or condition is one of several disorders of the appendicular bones, in which the appendicular bones require surgical intervention to fuse the bones together or repair a defect. 
     
     
         14 . The method of  claim 9 , wherein the human disease or condition is a bone void or defect that is not intrinsic to the stability of a bone structure, wherein the bone void or defect is created by surgery or traumatic injury, and wherein the bone graft composition fills the bone void or defect. 
     
     
         15 . The method of  claim 10 , wherein the human disease or condition is a cancer. 
     
     
         16 . The method of  claim 10 , wherein the human disease or condition is one of several disorders of the spinal vertebral bones that requires surgical intervention to fuse the vertebral bones together. 
     
     
         17 . The method of  claim 10 , wherein the human disease or condition is one of several disorders of the appendicular bones, in which the appendicular bones require surgical intervention to fuse the bones together or repair a defect. 
     
     
         18 . The method of  claim 10 , wherein the human disease or condition is a bone void or defect that is not intrinsic to the stability of a bone structure, wherein the bone void or defect is created by surgery or traumatic injury, and wherein the bone graft composition fills the bone void or defect. 
     
     
         19 . The bone graft composition of  claim 1 , wherein the density is from 1 g/mL to 6 g/mL. 
     
     
         20 . The bone graft composition of  claim 1 , wherein the collagen particle size is from 25 microns to 750 microns. 
     
     
         21 . The method of  claim 8 , wherein the calcium phosphate putty comprises biphasic calcium phosphate particles. 
     
     
         22 . The method of  claim 21 , wherein the biphasic calcium phosphate particles comprise hydroxyapatite and tricalcium phosphate. 
     
     
         23 . The method of  claim 22 , wherein the biphasic calcium phosphate particles comprise about 20-60% hydroxyapatite and about 40-80% tricalcium phosphate. 
     
     
         24 . The method of  claim 8 , wherein the bone graft composition further comprises an active agent. 
     
     
         25 . The method of  claim 24 , wherein the active agent is delivered at a controlled rate. 
     
     
         26 . The method of  claim 25 , wherein the active agent is selected from the group consisting of naloxone, naltrexone, and a salt thereof. 
     
     
         27 . The method of  claim 8 , wherein the acidifying agent comprises one or more selected from the group of ascorbic acid, magnesium citrate, potassium citrate, sodium citrate, citric acid monohydrate, and acetic acid. 
     
     
         28 . The method of  claim 8 , wherein the bone graft composition comprises a hardening agent. 
     
     
         29 . The method of  claim 28 , wherein the bone graft composition comprises an agent that controls the rate of curing. 
     
     
         30 . The method of  claim 29 , wherein the bone graft composition comprises an iron excipient. 
     
     
         31 . The method of  claim 30 , wherein the bone graft composition comprises collagen. 
     
     
         32 . The method of  claim 31 , wherein the bone graft composition comprises a diluent solution.