Carboxymethyl Cellulose and Method of Preparation

Abstract

Provided is a method for producing a cellulose derivative. The method includes forming a first reaction product by reacting non-oxidized cellulose with at least one first alkalization agent in the presence of at least one suitable solvent, wherein the first reaction product includes a non-oxidized alkali-cellulose. The method further includes forming a second reaction product by reacting a monohalo-organic compound with a second alkalization agent in a solution, wherein the second reaction product includes a saturated solution and a sediment. The method further includes increasing a temperature of the saturated solution and dissolving at least a portion of the sediment, and reacting the non-oxidized alkali-cellulose with the second reaction product to form an improved carboxymethyl cellulose.

1 - 36 . 
     
     
         37 . A hemostatic device comprising a plurality of repeating units of non-oxidized cellulose, wherein the plurality of repeating units of the non-oxidized cellulose comprise a plurality of side chains of CH 2 COONa bound to one of three hydroxyl groups of each repeating unit, and wherein the plurality of side chains comprise an ionic end group of a carboxyl group (COO—) with a Na +  counter ion. 
     
     
         38 . The hemostatic device of  claim 37 , wherein when the hemostatic device comes in contact with aqueous fluids comprising water, the non-oxidized cellulose interacts with the water resulting in dissociation of the Na+ counter ion from the plurality of side chains. 
     
     
         39 . The hemostatic device of  claim 37 , wherein the non-oxidized cellulose further comprises a plurality of additional side chains, wherein the additional side chains comprise mono-, di-, or tri-valent cations. 
     
     
         40 . The hemostatic device of  claim 39 , wherein the mono-, di-, or tri-valent cations are selected from the group consisting of K + , Ca +2 , Al +3 , and Ag + . 
     
     
         41 . The hemostatic device of  claim 37 , wherein the hemostatic device forms a hemodynamic gel when in contact with blood associated with a wound. 
     
     
         42 . The hemostatic device of  claim 41 , wherein the blood comprises platelets and coagulation factors, and the hemodynamic gel maintains platelets and coagulation factors within the gel. 
     
     
         43 . The hemostatic device of  claim 41 , wherein the hemodynamic gel adheres to the wound and creates pressure to seal the wound. 
     
     
         44 . The hemostatic device of  claim 37 , wherein the hemostatic device can absorb up to about 2500 percent of its own weight when fully immersed in aqueous media. 
     
     
         45 . The hemostatic device of  claim 37 , wherein the hemostatic device can stop external bleeding occurring from an open wound without the need of an application of pressure. 
     
     
         46 . The hemostatic device of  claim 37 , wherein the hemostatic device has a conductivity of greater than 3 mS after about 50 minutes. 
     
     
         47 . The hemostatic device of  claim 37 , wherein the non-oxidized cellulose comprises fibers, and the length of the fibers is preserved. 
     
     
         48 . A method of stopping or reducing bleeding from a wound, comprising applying a hemostatic device comprising a plurality of repeating units of non-oxidized cellulose to a bleeding wound without a need of application of external pressure to the hemostatic device, wherein the plurality of repeating units of the non-oxidized cellulose comprise a plurality of side chains of CH 2 COONa bound to one of three hydroxyl groups of each repeating unit, and wherein the plurality of side chains comprise an ionic end group of a carboxyl group (COO—) with a Na +  counter ion. 
     
     
         49 . The method of  claim 48 , wherein when the hemostatic device comes in contact with aqueous fluids comprising water, the non-oxidized cellulose interacts with the water resulting in dissociation of the Na+ counter ion from the plurality of side chains. 
     
     
         50 . The method of  claim 48 , wherein the hemostatic device forms a hemodynamic gel when in contact with blood associated with the wound. 
     
     
         51 . The method of  claim 50 , wherein the blood comprises platelets and coagulation factors, and the hemodynamic gel maintains platelets and coagulation factors within the gel. 
     
     
         52 . The method of  claim 50 , wherein the hemodynamic gel adheres to the wound and creates pressure to seal the wound. 
     
     
         53 . The method of  claim 48 , wherein the hemostatic device can absorb up to about 2500 percent of its own weight when fully immersed in aqueous media. 
     
     
         54 . The method of  claim 48 , wherein the hemostatic device has a conductivity of greater than 3 mS after about 50 minutes.