Novel Cannabinoid Carrier Compositions Having Enhance Pharmacokinetic Properties And Methods of Use Thereof

Abstract

Generally, the inventive technology relates to systems, methods, and compositions to formulate short-chain fatty acid phenolic compounds, such as cannabinoids, terpenes and other volatile compounds found in cannabinoid-producing plants such as Cannabis. In one embodiment, a natural or treated aloe vera extract may act as a cannabinoid-carrier and/or solubilizing agent forming one or more cannabinoid-infused aloe vera extract compositions, generally referred to herein as a composition or formulation of the invention. In one preferred aspect, the formulations and compositions of the invention may include safer and more palatable cannabinoid-delivery methods for both medicine and recreation. The formulations and compositions of the invention may further exhibit enhanced pharmacokinetic properties, such as enhanced bioavailability and increase adsorption in the gastrointestinal system.

1 . A composition comprising an aloe vera extract containing one or more cannabinoid compounds wherein said one or more cannabinoid compounds have enhanced solubility properties. 
     
     
         2 . The composition of  claim 1 , wherein said one or more cannabinoid compounds comprises a  Cannabis  extract. 
     
     
         3 . The composition of  claim 1 , wherein said one or more cannabinoid compounds comprises cannabidiol (CBD). 
     
     
         4 . (canceled) 
     
     
         5 . The composition of  claim 1 , wherein said one or more cannabinoid compounds have an enhanced absorption profile. 
     
     
         6 . The composition of  claim 1 , wherein said one or more cannabinoid compounds have enhanced analgesic properties. 
     
     
         7 . The composition of  claim 1 , wherein said composition is configured for oral administration. 
     
     
         8 . The composition of  claim 1 , wherein said aloe vera extract comprises an aloe vera extract derived from  Aloe barbadensis  Miller, or  Aloe aborescens.    
     
     
         9 . The composition of  claim 1 , wherein said aloe vera extract comprises an aloe vera extract that is charcoal activated such that anthraquinones, anthrones and/or insoluble fibers are removed from the extract, or wherein said aloe vera extract is a whole leaf extract that is charcoal activated such that anthraquinones, anthrones and/or insoluble fibers are removed the extract 
     
     
         10 - 11 . (canceled) 
     
     
         12 . The composition of  claim 2 , wherein said  Cannabis  extract comprises: a full-spectrum  Cannabis  extract, a cannabinoid isolate, one or more terpenes, one or more terpenoids, one or more phytonutrients, a hemp extract, or a mixture of the same. 
     
     
         13 . The composition of  claim 3 , wherein said CBD comprises 6-7% % w/v of the composition. 
     
     
         14 . The composition of  claim 3 , wherein said CBD comprises a full-spectrum CBD extract that further comprises 9-10% % w/v of the composition. 
     
     
         15 . The composition of  claim 8 , wherein said aloe vera extract comprises one or more active ingredients selected from the group consisting of: aloe-emodin, aloetic-acid, anthranol, aloin A and B, isobarbaloin, emodin, ester of cinnamic acid, pure mannan, acetylated mannan, acetylated glucomannan, glucogalactomannan, galactan, galactogalacturan, arabinogalactan, galactoglucoarabinomannan, pectic substance, xylan, cellulose, 8-C-glucosyl-(2′-O-cinnamoyl)-7-O-methylaloediol A, 8-C-glucosyl-(S)-aloesol, 8-C-glucosyl-7-O-methyl-(S)-aloesol, 8-C-glucosyl-7-O-methyl-aloediol, 8-C-glucosyl-noreugenin, isoaloeresin D, isorabaichromone, neoaloesin A, alkaline phosphatase, amylase, carboxypeptidase, catalase, cyclooxidase, cyclooxygenase, lipase, oxidase, phosphoenolpyruvate carboxylase, superoxide dismutase, calcium, chlorine, chromium, copper, iron, magnesium, manganese, potassium, phosphorous, sodium, zinc, calcium, chlorine, chromium, copper, iron, magnesium, manganese, potassium, phosphorous, sodium, zinc, arachidonic acid, y-linolenic acid, steroids (campestrol, cholesterol, β-sitosterol), triglicerides, triterpenoid, gibberillin, lignins, potassium sorbate, salicylic acid, uric acid, alanine, arginine, aspartic acid, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, phenylalanine, proline, threonine, tyrosine, valine, lectins, lectin-like substance, mannose, glucose, L-rhamnose, aldopentose, vitamin B1, vitamin B2, vitamin B6, vitamin C, β-carotene, choline, folic acid, and a-tocopherol. 
     
     
         16 - 22 . (canceled) 
     
     
         23 . A composition having enhanced cannabinoid delivery comprising:
 an aloe vera extract infused with a  Cannabis  extract wherein said  Cannabis  extract interacts with one or more active ingredients of said aloe vera extract, and wherein said interaction produces
 increased solubility of said  Cannabis  extract. 
   
     
     
         24 . The composition of  claim 23 , wherein said aloe vera extract comprises an aloe vera extract derived from  Aloe barbadensis  Miller, or  Aloe aborescens , or wherein said aloe vera extract is charcoal activated such that anthraquinones and/or insoluble fibers are removed, or wherein said aloe vera extract is a whole leaf extract that is charcoal activated such that anthraquinones and/or insoluble fibers are removed. 
     
     
         25 - 26 . (canceled) 
     
     
         27 . The composition of claim  26 , wherein said  Cannabis  extract comprises: a full-spectrum  Cannabis  extract, a cannabinoid isolate, one or more terpenes, one or more terpenoids, one or more phytonutrients, a hemp extract, or a mixture of the same. 
     
     
         28 . The composition of  claim 23 , wherein said  Cannabis  extract comprises a cannabidiol (CBD) extract. 
     
     
         29 . The composition of  claim 28 , wherein said composition has at least one of the following:
 increased bioavailability of said  Cannabis  extract when administered to a subject in need thereof;   enhanced therapeutic action of said  Cannabis  extract when administered to a subject in need thereof; and   enhanced synergistic action of said  Cannabis  extract and said one or more active ingredients in the aloe vera extract producing a novel activation pattern of one or more cannabinoid receptors when administered to a subject in need thereof.   
     
     
         30 . (canceled) 
     
     
         31 . The composition of  claim 23 , wherein said one or more active ingredients of said aloe vera extract comprises one or more active ingredients selected from the group consisting of: aloe-emodin, aloetic-acid, anthranol, aloin A and B, isobarbaloin, emodin, ester of cinnamic acid, pure mannan, acetylated mannan, acetylated glucomannan, glucogalactomannan, galactan, galactogalacturan, arabinogalactan, galactoglucoarabinomannan, pectic substance, xylan, cellulose, 8-C-glucosyl-(2′-O-cinnamoyl)-7-O-methylaloediol A, 8-C-glucosyl-(S)-aloesol, 8-C-glucosyl-7-O-methyl-(S)-aloesol, 8-C-glucosyl-7-O-methyl-aloediol, 8-C-glucosyl-noreugenin, isoaloeresin D, isorabaichromone, neoaloesin A, alkaline phosphatase, amylase, carboxypeptidase, catalase, cyclooxidase, cyclooxygenase, lipase, oxidase, phosphoenolpyruvate carboxylase, superoxide dismutase, calcium, chlorine, chromium, copper, iron, magnesium, manganese, potassium, phosphorous, sodium, zinc, calcium, chlorine, chromium, copper, iron, magnesium, manganese, potassium, phosphorous, sodium, zinc, arachidonic acid, γ-linolenic acid, steroids (campestrol, cholesterol, β-sitosterol), triglicerides, triterpenoid, gibberillin, lignins, potassium sorbate, salicylic acid, uric acid, alanine, arginine, aspartic acid, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, phenylalanine, proline, threonine, tyrosine, valine, lectins, lectin-like substance, mannose, glucose, L-rhamnose, aldopentose, vitamin B1, vitamin B2, vitamin B6, vitamin C, β-carotene, choline, folic acid, and a-tocopherol. 
     
     
         32 - 50 . (canceled) 
     
     
         51 . A composition comprising an aloe vera extract containing cannabidiol (CBD) wherein said CBD has enhanced solubility. 
     
     
         52 . A method for treating a disease condition, comprising administering to a subject in need of treatment thereof a therapeutically effective amount of the composition of any of  claim 51 . 
     
     
         53 . The method of  claim 52 , wherein said disease condition is selected from the group consisting of: chronic pain associated with interstitial cystitis, rheumatoid arthritis, fibromyalgia, nerve damage, and osteoarthritis.