Body fluid expanders comprising n-substituted aminosulfonic acid buffers

Abstract

A buffered body fluid expander solution, in which the buffer is a physiologically acceptable buffer that is not an inorganic phosphate buffer, comprises calcium ions and magnesium ions at a concentration ratio of 5:1 to 1:1. The solutions are useful for the manufacture of medicaments and blood volume expanders, for treating hypovolemia or for treating the loss of extracellular and interstitial fluid in subjects suffering with burns, for treating respiratory and/or metabolic acidosis in a subject, for perfusion of the abdominal cavity during peritoneal dialysis of a subject with acute renal failure or an acute toxicity condition, for preventing and/or ameliorating reperfusion injury, and for delivering a therapeutic, test and/or synergistic agent to a subject, including a biological agent, such as at least one stem cell, peptide or genomic derived protein.

1 - 20 . (canceled) 
     
     
         21 . A method of treating a burn, comprising administering to a subject in need thereof an effective amount of a solution comprising:
 (i) N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), wherein BES is present at a concentration of from 1 to 12 mmoles/L;   (ii) calcium ions and magnesium ions at a molar concentration ratio of 5:1 to 1:1, wherein said calcium ions are at a concentration of from 1.1 to 1.5 mmoles/L;   (iii) from 21 to 35 mmoles/L hydrogen carbonate ions;   (iv) from 100 to 150 mmoles/L sodium ions;   (v) from 2.5 to 6.2 mmoles/L potassium ions; and   (vi) from 96 to 126 mmoles/L chloride ions.   
     
     
         22 . The method of  claim 21 , wherein the solution is administered topically. 
     
     
         23 . The method of  claim 21 , wherein the solution is administered systemically. 
     
     
         24 . The method of  claim 21 , wherein the treatment compensates for the loss of interstitial and/or extracellular fluid resulting from or associated with the burn. 
     
     
         25 . The method of  claim 21 , wherein the subject is a human. 
     
     
         26 . A method of treating the loss of interstitial and/or extracellular fluid in a subject suffering from a burn, the method comprising administering to the subject an effective amount of a solution comprising:
 (i) N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), wherein BES is present at a concentration of from 1 to 12 mmoles/L;   (ii) calcium ions and magnesium ions at a molar concentration ratio of 5:1 to 1:1, wherein said calcium ions are at a concentration of from 1.1 to 1.5 mmoles/L;   (iii) from 21 to 35 mmoles/L hydrogen carbonate ions;   (iv) from 100 to 150 mmoles/L sodium ions;   (v) from 2.5 to 6.2 mmoles/L potassium ions; and   (vi) from 96 to 126 mmoles/L chloride ions.   
     
     
         27 . The method of  claim 26 , wherein the solution is administered topically. 
     
     
         28 . The method of  claim 26 , wherein the solution is administered systemically. 
     
     
         29 . The method of  claim 26 , wherein the subject is a human.