US2021389296A1PendingUtilityA1
Non-hydrogen-bonding universal reader for dna sequencing
Est. expiryAug 22, 2036(~10.1 yrs left)· nominal 20-yr term from priority
C07C 321/10G01N 33/48721C12Q 1/6869C07C 2603/50
67
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Claims
Abstract
The present disclosure provides apparatus and methods for determining the sequence of a nucleic acid. The apparatus comprises electrodes that form a tunnel gap through which the nucleic acid can pass. The electrodes comprise a reagent that is capable of selectively interacting with a nucleobase of the nucleic acid sequence. When the reagent interacts with a nucleobase, a detectable signal is produced and used to identify the nucleobase of the nucleic acid. Advantageously, the apparatus of this disclosure is specific to identifying nucleic acids.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A compound of formula (I):
wherein R 1 is (C 1 -C 6 ) alkyl or (C 1 -C 6 ) alkoxy;
R 2 is selected from the group consisting of thiol, disulfide, and amine; and
R 3 is H, an electron withdrawing group or an electron donating group;
ring A or ring B is substituted with R 1 -R 2 ; and
ring C or ring D is substituted with R 3 ;
provided that (i) when ring A is substituted with R 1 -R 2 , ring C is substituted with R 3 ; and (ii) when ring B is substituted with R 1 -R 2 , ring D is substituted with R 3 .
2 . The compound of claim 1 , wherein R 1 is (C 1 -C 6 ) alkyl.
3 . The compound of claim 1 , wherein R 1 is (C 1 -C 3 ) alkyl.
4 . The compound of claim 1 , wherein R 1 is ethyl.
5 . The compound of claim 1 , wherein R 2 is thiol.
6 . The compound of claim 2 , wherein R 2 is thiol.
7 . The compound of claim 1 , wherein R 3 is H, —NO 2 or —CH 3 .
8 . The compound of claim 6 , wherein R 3 is H, —NO 2 or —CH 3 .
9 . The compound of claim 1 , wherein R 3 is H.
10 . The compound of claim 8 , wherein R 3 is H
11 . The compound of claim 1 , wherein said compound is formula (Ia):
wherein R 1 is (C 1 -C 6 ) alkyl or (C 1 -C 6 ) alkoxy; and
R 2 is selected from the group consisting of thiol, disulfide, and amine.
12 . The compound of claim 11 , wherein R 1 is (C 1 -C 6 ) alkyl.
13 . The compound of claim 11 , wherein R 1 is (C 1 -C 3 ) alkyl.
14 . The compound of claim 11 , wherein R 1 is ethyl.
15 . The compound of claim 11 , wherein R 2 is thiol.
16 . The compound of claim 12 , wherein R 2 is thiol.
17 . The compound of claim 13 , wherein R 2 is thiol.
18 . The compound of claim 14 , wherein R 2 is thiol.
19 . A compound of formula (I):
wherein R 1 is (C 1 -C 3 ) alkyl;
R 2 is thiol; and
R 3 is H;
ring A or ring B is substituted with R 1 -R 2 ; and
ring C or ring D is substituted with R 3 ;
provided that (i) when ring A is substituted with R 1 -R 2 , ring C is substituted with R 3 ; and (ii) when ring B is substituted with R 1 -R 2 , ring D is substituted with R 3 .
20 . The compound of claim 19 , wherein said compound is formula (Ia):Join the waitlist — get patent alerts
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