US2021386878A1PendingUtilityA1

System and Process for Production of Isotopes and Isotope Compositions

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Assignee: BATTELLE MEMORIAL INSTITUTEPriority: Oct 19, 2016Filed: Aug 30, 2021Published: Dec 16, 2021
Est. expiryOct 19, 2036(~10.2 yrs left)· nominal 20-yr term from priority
Inventors:Matthew J. O'Hara
G21G 1/001C22B 3/20C01G 25/003B01D 59/30A61K 51/0474A61K 51/1093Y02P10/20C22B 34/14C22B 3/24G21G 4/08B01D 59/24A61K 51/10
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Claims

Abstract

Methods for purifying 89 Zr are provided, 89 Zr compositions are provided, isotope compositions are provided that can include: a radio isotope and a nanoparticle, and methods for radio labeling monoclonal antibodies are provided.

Claims

exact text as granted — not AI-modified
1 . A method for radio labeling monoclonal antibodies, the method comprising preparing a binding conjugate by exposing a ligand to a solution of  89 Zr and less than 1 M oxalic acid. 
     
     
         2 . The method of  claim 1  wherein the solution comprises from 0.3 M to less than 1 M oxalic acid. 
     
     
         3 . The method of  claim 1  wherein the solution further comprises fluoride. 
     
     
         4 . The method of  claim 3  wherein the solution further comprises NaF. 
     
     
         5 . The method of  claim 1  wherein the conjugate comprises mAbs. 
     
     
         6 . The method of  claim 5  wherein the conjugate comprises deferoxamine.

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