Aerosolisable formulation

Abstract

An aerosolizable formulation comprising (i) water in an amount of at least 50 wt. % based on the aerosolizable formulation; and (ii) nicotine; wherein the nicotine is present in an amount of no greater than 1 wt. % based on the aerosolizable formulation. A process for forming an aerosol comprising the aerosolizable formulation, the aerosolizable formulation contained in a container, and an electronic aerosol provision system having an aerosolizer for aerosolizing the aerosolizable formulation for inhalation by a user.

1 . An aerosolizable formulation comprising:
 (i) water in an amount of at least 50 wt. % based on the aerosolizable formulation; and   (ii) nicotine;   wherein the nicotine is present in an amount of no greater than 1 wt. % based on the aerosolizable formulation.   
     
     
         2 . An aerosolizable formulation according to claim wherein water is present in an amount of at least 70 wt. % based on the aerosolizable formulation. 
     
     
         3 . An aerosolizable formulation according to claim wherein water is present in an amount of at least 80 wt. % based on the aerosolizable formulation. 
     
     
         4 . An aerosolizable formulation according to  claim 1 , wherein water is present in an amount of at least 90 wt. % based on the aerosolizable formulation. 
     
     
         5 . An aerosolizable formulation according to  claim 1 , wherein the nicotine is present in an amount of no greater than 0.6 wt. % based on the aerosolizable formulation. 
     
     
         6 . An aerosolizable formulation according to  claim 1 , wherein the nicotine is present in an amount of no greater than 0.3 wt. % based on the aerosolizable formulation. 
     
     
         7 . An aerosolizable formulation according to  claim 6 , wherein the nicotine is present in an amount of from 0.15 to 0.3 wt. % based on the aerosolizable formulation. 
     
     
         8 . An aerosolizable formulation according to  claim 1 , further comprising an acid. 
     
     
         9 . An aerosolizable formulation according to claim wherein the acid is selected from the group consisting of acetic acid, lactic acid, formic acid, citric acid, benzoic acid, pyruvic acid, levulinic acid, succinic acid, tartaric acid, sorbic acid, propionic acid, phenylacetic acid, and mixtures thereof. 
     
     
         10 . An aerosolizable formulation according to claim wherein the acid is selected from the group consisting of citric acid, benzoic acid, levulinic acid, sorbic acid, lactic acid, and mixtures thereof. 
     
     
         11 . An aerosolizable formulation according to  claim 8 , wherein the acid comprises is at least citric acid. 
     
     
         12 . An aerosolizable formulation according to  claim 8 , wherein a total content of acid present in the formulation is no greater than 1 mole equivalents based on the nicotine. 
     
     
         13 . An aerosolizable formulation according to  claim 8 , wherein a total content of acid present in the solution is no less than 0.1 mole equivalents based on the nicotine. 
     
     
         14 . An aerosolizable formulation according to  claim 1 , further comprising one or more flavors. 
     
     
         15 . An aerosolizable formulation according to  claim 14 , wherein the one or more flavors are selected from the group consisting of (4-(para-) methoxyphenyl)-2-butanone, vanillin, γ-undecalactone, menthone, 5-propenyl guaethol, menthol, para-mentha-8-thiol-3-one and mixtures thereof. 
     
     
         16 . An aerosolizable formulation according to  claim 15 , wherein the one or more flavors comprises menthol. 
     
     
         17 . An aerosolizable formulation according to  claim 14 , wherein the one or more flavors are present in a total amount of no greater than 2 wt. % based on the aerosolizable formulation. 
     
     
         18 . An aerosolizable formulation according to  claim 14 , wherein the one or more flavors are present in a total amount of from 0.01 to 1 wt. % based on the aerosolizable formulation. 
     
     
         19 . An aerosolizable formulation according to  claim 1 , further comprising one or more cyclodextrins, wherein the aerosolizable formulation contains no flavors that can be encapsulated by the one or more cyclodextrins. 
     
     
         20 . An aerosolizable formulation according to  claim 1 , further comprising one or more cyclodextrins, wherein the aerosolizable formulation contains no flavors. 
     
     
         21 . A process for forming an aerosol, the process comprising:
 aerosolising an aerosolizable formulation comprising
 (i) water in an amount of at least 50 wt. % based on the aerosolizable formulation; and 
 (ii) nicotine; 
   wherein the nicotine is present in an amount of no greater than 1 wt. % based on the aerosolizable formulation.   
     
     
         22 . (canceled) 
     
     
         23 . A process according to  claim 21 , wherein the aerosolizable formulation is aerosolized to form the aerosol at a temperature below 50° C. 
     
     
         24 . A process according to  claim 21 , wherein aerosolizing the aerosolizable formulation comprises applying ultrasonic energy to the aerosolizable formulation. 
     
     
         25 . A contained aerosolizable formulation comprising:
 (a) a container; and   (b) an aerosolizable formulation comprising:
 (i) water in an amount of at least 50 wt. % based on the aerosolizable formulation; and 
 (ii) nicotine; 
   wherein the nicotine is present in an amount of no greater than 1 wt. % based on the aerosolizable formulation.   
     
     
         26 . (canceled) 
     
     
         27 . A contained aerosolizable formulation according to  claim 25 , wherein the container is configured for engagement with an electronic aerosol provision system. 
     
     
         28 . An electronic aerosol provision system comprising:
 (a) an aerosolizer for aerosolizing an aerosolizable formulation for inhalation by a user of the electronic aerosol provision system;   (b) a power supply comprising a cell or battery for supplying power to the aerosolizer   (c) an aerosolizable formulation comprising:
 (i) water in an amount of at least 50 wt. % based on the aerosolizable formulation; and 
 (ii) nicotine; 
   wherein the nicotine is present in an amount of no greater than 1 wt. % based on the aerosolizable sable formulation.   
     
     
         29 . (canceled)