Lithium fluoride nanoparticles for the protection of chondrocytes in osteoarthritis

Abstract

Disclosed are particles comprising lithium salts and methods for their use in treating inflammatory conditions.

1 . A particle comprising a lithium salt core and an encapsulating shell. 
     
     
         2 . The particle of  claim 1 , wherein the lithium salt is selected from the group consisting of lithium fluoride (LiF) salt, lithium bromide (LiBr) salt, lithium chloride (LiCl) salt, lithium iodide (LiI) salt, lithium aluminum oxide (LiALO 2 ) salt, Lithium phosphate (Li 3 PO 4 ), Lithium carbonate (LiCO 3 ) salt, and lithium tantalum oxide (LiTaO 3 ) salt. 
     
     
         3 . The particle of  claim 2 , wherein the lithium salt is LiF. 
     
     
         4 . The particle of  claim 2 , wherein the concentration of LiF salt comprises 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 mM. 
     
     
         5 . The particle of  claim 1 , wherein the lithium core further comprises an eluting matrix; that releases the Li salt from the matrix over a sustained rate. 
     
     
         6 . The particle of  claim 5 , wherein the eluting matrix comprises hyaluronic acid. 
     
     
         7 . The particle of  claim 5 , wherein the lithium salt is synthesized in synthesis matrix comprises a polyethylene glycol (PEG) and ethylene glycol (EG) mixture. 
     
     
         8 . The particle of  claim 7 , wherein the PEG:EG ration is 1:1. 
     
     
         9 . The particle of  claim 1 , wherein the lithium core comprises a diameter between about 90 nm and 110 nm. 
     
     
         10 . The particle of  claim 1 , wherein the diameter of the lithium core is 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, or 110 nm. 
     
     
         11 . The particle of  claim 1 , wherein the encapsulating shell comprises a silica shell. 
     
     
         12 . The particle of  claim 1 , wherein the encapsulating shell has a thickness of about 20 nm. 
     
     
         13 . The particle of  claim 11 , wherein the silica shell comprises Tetraethyl orthosilicate. 
     
     
         14 . A pharmaceutical composition comprising the particle of  claim 1 . 
     
     
         15 . The pharmaceutical composition of  claim 14 , further comprising hyaluronic acid. 
     
     
         16 . A method of treating an inflammatory disease in a subject comprising administering to the subject the particle of  claim 1 . 
     
     
         17 . The method of  claim 16 , wherein the inflammatory disease is osteoarthritis. 
     
     
         18 . The method of  claim 16 , wherein the composition is administered intra articularly.