Syringe infusion devices and systems for delivery of active agents

Abstract

A pump device (10) operable with a syringe (11) having a barrel (12) and a plunger (13). The pump device (10) is operable to cause relative movement between the syringe plunger (13) and the syringe barrel (12) for discharging fluid from the syringe (11). The pump device (10) comprises a portion (31) adapted to engage the syringe barrel (12), and a drive mechanism for moving the syringe plunger (13) relative to the syringe barrel (12) to discharge fluid from the syringe (11). The drive mechanism comprises an actuator (45) adapted to engage the syringe plunger (13) and a power mechanism (61) for moving the actuator (45) to effect movement of the syringe plunger (13) relative to the syringe barrel (12). The pump device (10) thus provides a syringe driving means. There is also provided an infusion system comprising a syringe driving means, the syringe driving means comprising the pump device (10). Further, there is provided an infusion system comprising a syringe driving means operable to maintain a constant pressure within a syringe and tubing with viscosity corrections for various antibiotic concentrations.

1 .- 23 . (canceled) 
     
     
         24 . An infusion system comprising a syringe driving means operable to maintain a constant pressure within a syringe, and tubing with viscosity corrections for various antibiotic concentrations. 
     
     
         25 . The infusion system according to  claim 24 , wherein the tubing is calibrated to restrict the flow of fluid thereby delivering a selected profile of antibiotic 
     
     
         26 . The infusion system according to  claim 24 , wherein the tubing is calibrated to restrict the flow of fluid thereby delivering the ideal profile of antibiotic to maximise the concentration of antibiotic above the mean inhibitory concentration (MIC) of the antibiotic to a patient in need thereof. 
     
     
         27 . A kit comprising a syringe, a syringe driving means and tubing calibrated for delivering a pre-determined amount of an antibiotic in a pre-determined time period. 
     
     
         28 . The kit according to  claim 27 , wherein the tubing is calibrated for use with an antibiotic solution is also provided by the present invention. 
     
     
         29 . The kit according to  claim 27 , wherein the syringe driving means comprises a pump device. 
     
     
         30 . The kit according to  claim 29 , wherein the pump device comprises a pump device operable with a syringe having a barrel and a plunger, the pump device being operable to cause relative movement between the syringe plunger and the syringe barrel for discharging fluid from the syringe, the pump device comprising a portion adapted to engage the syringe barrel, and a drive mechanism for moving the syringe plunger relative to the barrel to discharge fluid from the syringe, the drive mechanism comprising (1) a piston adapted for guided movement along a path, configured to stay outside the barrel during the relative movement between the plunger and the barrel and having a cylindrical side wall, and (2) a power mechanism for moving the piston to effect movement of the syringe plunger relative to the barrel, wherein the power mechanism comprises two spring mechanisms operable to exert a spring force on the piston,
 wherein each spring mechanism comprises a reel and a flexible link, the flexible link having a proximal end attached to the reel and a distal end directly attached to the piston,   wherein the flexible link is windable onto and from the reel,   wherein each reel is mounted on an axle supported between two housing sections of the pump device; and   wherein the piston comprises a base portion and an upper end face, the base portion is configured to define two opposing mounting lugs each directly attached to one distal end of one flexible link and a web functioning as a bridge extending between the lugs and the upper end face of the piston is adapted to directly engage the plunger.   
     
     
         31 . An infusion system comprising a syringe driving means operable to maintain a constant pressure within a syringe, and tubing with viscosity corrections for various antibiotic concentrations, wherein the tubing has been calibrated according to the information in  FIGS. 12 to 15 .