Treatment or prevention of anaemia in pregnant non-human mammals

Abstract

The present invention relates to an iron carbohydrate complex for use in a method of increasing the blood haemoglobin concentration in a pregnant non-human mammal, wherein the pregnant non-human mammal having a blood haemoglobin level of 105 g/L or less, is administered one or more doses of iron carbohydrate complex comprising an amount of elemental iron of 1800 mg or more per dose. The method relates to the further effects of decreasing the rate of stillborn offsprings from a pregnant non-human mammal having a blood haemoglobin level of 105 g/L or less, increasing the blood haemoglobin concentration of offspring litters within 3 days from birth and/or weaning, or increasing the litter size in a subsequent parity of a non-human mammal having a blood haemoglobin level of 105 g/L or less.

What is claimed is: 
     
         1 - 78 . (canceled) 
     
     
         79 . A method of increasing the percentage of liveborn offspring from a pregnant non-human mammal, wherein the pregnant non-human mammal having a blood haemoglobin level of 105 g/L or less is administered one or more doses of an iron carbohydrate complex in an amount of 1800 mg or more elemental iron per dose or in an amount of 6 mg/kg BW (body weight) elemental iron or more per dose. 
     
     
         80 . A method of increasing the survival, health and/or growth of an offspring litter of a pregnant non-human mammal until weaning, wherein the pregnant non-human mammal having a blood haemoglobin level of 105 g/L or less is administered one or more doses of an iron carbohydrate complex in an amount of 1800 mg or more elemental iron per dose or in an amount of 6 mg/kg BW (body weight) elemental iron or more per dose. 
     
     
         81 . A method of decreasing the percentage of stillborn and/or mummified offspring from a pregnant non-human mammal and/or decreasing the mortality in the suckling period of offspring from a pregnant non-human mammal, wherein the pregnant non-human mammal having a blood haemoglobin level of 105 g/L or less is administered one or more doses of an iron carbohydrate complex in an amount of 1800 mg or more elemental iron per dose or in an amount of 6 mg/kg BW (body weight) elemental iron or more per dose. 
     
     
         82 . The method according to  claim 80 , wherein the average survival rate until weaning is 80% or more such as 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 96%, 97%, 98%, 99% or more. 
     
     
         83 . The method according to  claim 80 , wherein the increased health of the offspring litter is expressed by increased weight gain and/or a higher blood haemoglobin concentration and/or increased survival rate until weaning. 
     
     
         84 . The method according to  claim 79 , wherein the non-human mammal is a pig. 
     
     
         85 . The method according to  claim 79 , wherein the dose of iron carbohydrate complex is administered parenterally. 
     
     
         86 . The method according to  claim 79 , wherein the dose of an iron carbohydrate complex is administered parenterally and wherein the parenteral administration is selected among the group consisting of intramuscular (IM) injection, subcutaneous (SC) injection, bolus injection, and intravenous (IV) injection or infusion. 
     
     
         87 . The method according to  claim 79 , wherein the dose is 1900 mg, 2000 mg, 2100 mg, 2200 mg, 2300 mg, 2400 mg, 2500 mg, 2600 mg, 2700 mg, 2800 mg, 2900 mg, 3000 mg, 3100 mg, 3200 mg, 3300 mg, 3400 mg, 3500 mg, 3600 mg, 3700 mg, 3800 mg, 3900 mg, 4000 mg 4100 mg, 4200 mg, 4300 mg, 4400 mg, 4500 mg, 4600 mg, 4700 mg, 4800 mg, 4900 mg, 5000 mg, 5100 mg, 5200 mg, 5300 mg, 5400 mg, 5500 mg, 5600 mg, 5700 mg, 5800 mg, 5900 mg, 6000 mg, 6100 mg, 6200 mg, 6300 mg, 6400 mg, 6500 mg, 6600 mg, 6700 mg, 6800 mg, 6900 mg, 7000 mg, 7100 mg, 7200 mg, 7300 mg, 7400 mg, 7500 mg, 7600 mg, 7700 mg, 7800 mg, 7900 mg, 8000 mg, 8100 mg, 8200 mg, 8300 mg, 8400 mg, 8500 mg, 8600 mg, 8700 mg, 8800 mg, 8900 mg, 9000 mg, 9100 mg, 9200 mg, 9300 mg, 9400 mg, 9500 mg, 9600 mg, 9700 mg, 9800 mg, 9900 mg, 10000 mg, or more. 
     
     
         88 . The method according  79 , wherein the dose consists of one, two or more injections performed on the same day. 
     
     
         89 . The method according to  claim 79 , wherein two injections or infusions are administered, as one injection or infusion in each side of the non-human mammal's neck, on the same day. 
     
     
         90 . The method according to  claim 79 , wherein two doses are administered, the first dose being administered 15 to 3 weeks prior to expected farrowing and the second dose being administered 8 to 1 weeks prior to expected farrowing. 
     
     
         91 . The method according to  claim 79 , wherein the dose is 6 mg/kg BW (body weight) elemental iron or more, preferably 6 mg/kg BW to 30 mg/kg BW elemental iron. 
     
     
         92 . The method according to  claim 79 , wherein the iron carbohydrate complex is selected from the group comprising iron carboxymaltose, iron polyglucose sorbitol carboxymethyl ether complex, iron dextran, iron hydrogenated dextran, iron sucrose, iron gluconate, iron polymaltose, iron hydrogenated polymaltose, iron sorbitol, iron glycoheptanoic acid and mixtures thereof. 
     
     
         93 . The method according to  claim 79 , wherein the iron carbohydrate complex is iron hydrogenated dextran. 
     
     
         94 . The method according to  claim 79 , wherein the weight average molecular weight (MW) of the carbohydrate component of the iron carbohydrate complex is 800 to 80,000 Dalton, preferably 800 to 10,000 Dalton. 
     
     
         95 . The method according to  claim 79 , wherein the apparent molecular weight of the iron carbohydrate complex is 500,000 Dalton or less, preferably 400,000 Dalton or less. 
     
     
         96 . The method according to  claim 79 , wherein the amount of reprotoxic conservatives in the formulation comprising iron carbohydrate complex is 1 g/L or less and optionally the reprotoxic conservative is phenol. 
     
     
         97 . The method according to  claim 79 , wherein the dose is administered in 2 minutes or less. 
     
     
         98 . The method according to  claim 79 , wherein the iron carbohydrate complex is formulated as an injectable veterinary composition and wherein the concentration of elementary iron of the iron carbohydrate complex in the injectable veterinary composition is in the range of 5 g/100 mL to 25 g/100 mL.