Systems for treating pulmonary infections

Abstract

Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

1 . A system for treating or providing prophylaxis against a pulmonary infection in a patient, comprising:
 (a) a pharmaceutical formulation comprising a liposomal complexed aminoglycoside, wherein the formulation is an aqueous dispersion, and the lipid component of the liposome consists of electrically neutral lipids, and   (b) a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 g per minute, wherein the mass median aerodynamic diameter (MMAD) of the aerosol is less than about 4.2 μm, as measured by the Anderson Cascade Impactor (ACI), or less than about 4.9 μm, as measured by the Next Generation Impactor (NGI).   
     
     
         2 .- 146 . (canceled)