Compounds and compositions for the treatment of parasitic diseases

Abstract

The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

We claim: 
     
         1 . A method for treating human African trypanosomiasis, comprising administering to a subject in need thereof a therapeutically effective amount of N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide, or a pharmaceutically acceptable salt thereof; and optionally in combination with a second agent. 
     
     
         2 . The method of  claim 1 , wherein said second agent is pentamidine, suramin, melarsoprol, eflornithine, nifurtimox or a combination thereof. 
     
     
         3 . The method of  claim 1 , wherein said second agent is pentamidine. 
     
     
         4 . The method of  claim 1 , wherein said second agent is suramin. 
     
     
         5 . The method of  claim 1 , wherein said second agent is melarsoprol. 
     
     
         6 . The method of  claim 1 , wherein said second agent is eflornithine. 
     
     
         7 . The method of  claim 1 , wherein said second agent is nifurtimox.