Compositions and Methods for Reducing Weight Gain

Abstract

The present invention provides methods for using reutericyclin or an analog thereof to reduce weight gain or induce weight loss in a mammal. Also provided herein are methods for using reutericyclin-producing Lactobacillus reuterii bacteria as a probiotic to reduce weight gain or to induce weight loss, particularly for subjects receiving an antibiotic or xenobiotic treatment.

We claim: 
     
         1 . A method of reducing and/or reversing weight gain in a human, the method comprising administering a therapeutically effective amount of reutericyclin to reduce weight gain or induce weight loss; wherein the human is being treated with an antibiotic or xenobiotic. 
     
     
         2 . A pharmaceutical composition comprising  Lactobacillus reuterii  LTH2584 and/or a lysate thereof; and a pharmaceutically acceptable carrier. 
     
     
         3 . A pharmaceutical composition comprising an antibiotic or xenobiotic medication; reutericyclin; and a pharmaceutically acceptable carrier. 
     
     
         4 . The pharmaceutical composition of  claim 3 , wherein the composition is formulated to be administered using a clinically accepted administration route. 
     
     
         5 . The pharmaceutical composition of  claim 3 , wherein the composition is formulated to be administered orally. 
     
     
         6 . The pharmaceutical composition of  claim 3 , wherein the composition comprises an amount of the reutericyclin, which is therapeutically effective to reduce weight gain and/or induce weight loss. 
     
     
         7 . The pharmaceutical composition of  claim 3 , wherein the antibiotic is selected from Amoxicillin, Ampicillin, Cefadroxil, Cephalexin, Clindamycin, Loracarbef, Metronidazole, Penicillin, Sulfisoxazole, Trimethroprim, Amoxicillin-Clavulanate, Ampicillin-Sulbactam Azithromycin, Cefoxitin, Ceftazidime, Ceftriaxone, Cefaclor, Cefdinir, Cefepime, Cefixime, Cefotaxime, Cefpodoxime, Cefprozil, Ceftibuten, Cefuroxime, Ciprofloxacin, Doxycycline, Gentamicin, Imipenem, Levofloxacin, Linezolid, Piperacillin-Tazobactam, Sulfamethoxazole-Trimethoprim, Tobramycin, Vancomycin. Macrolides: Azithromycin, Clarithromycin, Erythromycin, chlortetracycline, procaine, oxytetracycline, tylosin, bacitracin, neomycin sulfate, streptomycin, erythromycin, linomycin, oleandomycin, vancomycin, virginamycin, and bambermycin. 
     
     
         8 . The pharmaceutical composition of  claim 3 , wherein the composition comprises the xenobiotic medication, which comprises an antipsychotic medication. 
     
     
         9 . The pharmaceutical composition of  claim 8 , wherein the composition comprises an amount of reutericyclin, which is therapeutically effective to reduce weight gain and/or induce weight loss. 
     
     
         10 . The pharmaceutical composition of  claim 8 , wherein the composition comprises an atypical antipsychotic medication. 
     
     
         11 . The pharmaceutical composition of  claim 10 , wherein the atypical antipsychotic medication is olanzapine. 
     
     
         12 . The pharmaceutical composition of  claim 8 , wherein the antipsychotic medication is selected from the group consisting of risperidone, clozapine, olanzapine, quetiapine, and sertindole. 
     
     
         13 . The pharmaceutical composition of  claim 8 , wherein the composition is formulated to be administered orally; and the antipsychotic medication is risperidone. 
     
     
         14 . The pharmaceutical composition of  claim 8 , wherein the composition comprises a benzisoxazole antipsychotic medication. 
     
     
         15 . The pharmaceutical composition of  claim 14 , wherein the benzisoxazole antipsychotic medication is risperidone.