Enhanced production of fatty acid derivatives

Abstract

Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.

1 .- 7 . (canceled) 
     
     
         8 . A method for producing a fatty alcohol, the method comprising
 culturing, in the presence of a carbon source, a recombinant host cell,   wherein the recombinant host cell comprises at least one exogenous gene encoding a fatty acid derivative enzyme selected from: a thioesterase, an acyl-CoA synthase, an alcohol forming-CoA reductase, an acyl-CoA reductase, and an alcohol dehydrogenase.   
     
     
         9 . The method of  claim 8 , wherein
 the recombinant host cell comprises at least one exogenous thioesterase gene, an exogenous acyl-CoA synthase gene, and   at least one exogenous gene selected from the group consisting of an exogenous an acyl-CoA reductase gene, an exogenous alcohol dehydrogenase gene and an exogenous fatty alcohol forming acyl-CoA reductase gene.   
     
     
         10 . The method of  claim 9 , wherein the at least one thioesterase is: a thioesterase having EC number: EC 3.1.2.- or EC 3.1.1.5 or EC 3.1.2.14.