Tetrahydrocurcuminoid-metal complexes, manufacturing methods thereof, and uses thereof

Abstract

The invention is directed to tetrahydrocurcuminoid-metal complexes. The complexes can be included in compositions that further include additional nutraceutical antimicrobials, antioxidants, and immune boosters. The tetrahydrocurcuminoid-metal complexes can be administered to animals to increase animal health, reduce stress, reduce oxidative stress, maintain health, improve health, improve immunity, improve vaccination efficacy, increase feed conversion rate, decrease pro-inflammatory cytokine levels, or any combination thereof in an animal. The tetrahydrocurcuminoid-metal complexes of the invention exhibit enhanced bioavailability relative to the individual, non-complexed components.

1 . A tetrahydrocurcuminoid-metal complex comprising at least one tetrahydrocurcuminoid chelated to a metal. 
     
     
         2 . The tetrahydrocurcuminoid-metal complex of  claim 1 , wherein the tetrahydrocurcuminoid-metal complex is a tetrahydrocurcuminoid-metal-tetrahydrocurcuminoid complex. 
     
     
         3 . The tetrahydrocurcuminoid-metal complex of  claim 1 , wherein the tetrahydrocurcuminoid-metal complex is a tetrahydrocurcuminoid-metal-curcuminoid complex. 
     
     
         4 . The tetrahydrocurcuminoid-metal complex of  claim 3 , wherein the tetrahydrocurcuminoid-metal-curcuminoid complex comprises a curcuminoid selected from the group consisting of curcumin, demethoxycurcumin, and bisdemethoxycurcumin. 
     
     
         5 . The tetrahydrocurcuminoid-metal complex of  claim 1 , wherein the tetrahydrocurcuminoid-metal complex comprises a tetrahydrocurcuminoid selected from the group consisting of tetrahydrocurcumin, tetrahydrodemethoxycurcumin, and tetrahydrobisdemethoxycurcumin. 
     
     
         6 . The tetrahydrocurcuminoid-metal complex of  claim 1 , wherein the metal is a divalent metal. 
     
     
         7 . (canceled) 
     
     
         8 . The tetrahydrocurcuminoid-metal complex of  claim 1 , wherein the metal comprises zinc. 
     
     
         9 - 10 . (canceled) 
     
     
         11 . A composition comprising the tetrahydrocurcuminoid-metal complex of  claim 1 . 
     
     
         12 . The composition of  claim 11 , wherein the composition further comprises a carrier. 
     
     
         13 . The composition of  claim 11 , wherein the composition further comprises an active ingredient. 
     
     
         14 . The composition of  claim 13 , wherein the active ingredient comprises at least one of an antioxidant, an antimicrobial agent, and an immune boosting agent. 
     
     
         15 . (canceled) 
     
     
         16 . The composition of  claim 13 , wherein the active ingredient comprises ferulic acid, a  Spirulina  extract, and selenium. 
     
     
         17 . (canceled) 
     
     
         18 . A method of reducing stress, reducing oxidative stress, maintaining health, improving health, improving immunity, improving vaccination efficacy, increasing feed conversion rate, decreasing pro-inflammatory cytokine levels in an animal, or any combination thereof, the method comprising administering an effective amount of the composition of  claim 11  to the animal. 
     
     
         19 . The method of  claim 18 , wherein the animal is a mammal. 
     
     
         20 . The method of  claim 18 , wherein the animal is a human. 
     
     
         21 . The method of  claim 18 , wherein the animal is a non-human animal. 
     
     
         22 . The method of  claim 18 , wherein the animal is a production animal. 
     
     
         23 . The method of  claim 18 , wherein the animal is an avine, a bovine, an ovine, a reptilian, a porcine, and a caprine. 
     
     
         24 . The method of  claim 18 , wherein the composition is administered in an amount effective to increase feed conversion rate in the animal relative to a control animal not receiving the composition. 
     
     
         25 . The method of  claim 18 , wherein the composition is administered in an amount effective to decrease serum levels of at least one pro-inflammatory cytokine in the animal relative to a control animal not receiving the composition. 
     
     
         26 . The method of  claim 18 , wherein the composition is administered in an amount effective to decrease serum levels of at least one of IL-2, IL-8, IL-6, IL-7, IL-15, IL-18, MCP-1, TNFα, and IL-1-beta in the animal relative to a control animal not receiving the composition. 
     
     
         27 . The method of  claim 18 , wherein the animal is an animal suffering from a disease. 
     
     
         28 . The method of  claim 27 , wherein the disease comprises one of cancer, arthritis, an inflammatory condition, a cardiovascular condition, a neurological condition, a pulmonary condition, diabetes, a hepatic condition, a gastrointestinal condition, a viral disease, a prion disease, and an infectious disease. 
     
     
         29 . (canceled) 
     
     
         30 . The method of  claim 18 , wherein the composition is administered orally to the animal. 
     
     
         31 . The method of  claim 18 , wherein the composition is administered topically to the animal.