Dietary macro/micronutritional supplement for patients undergoing kidney dialysis

Abstract

Provided herein is a nutritional supplement designed to support kidney and cardiac function as well as mitochondrial energy function needs in patients undergoing hemodialysis. This supplement replenishes essential vitamins and minerals that are lost during dialysis, does not contain compounds that may specifically cause harm to dialysis patients, and provides support for tissues undergoing oxidative stress.

What is claimed: 
     
         1 . A unit dose composition comprising
 (a) vitamin B1   (b) vitamin B2   (c) vitamin B3   (d) vitamin B5   (e) vitamin B6   (f) vitamin B7   (g) vitamin B9   (h) vitamin B12   (i) vitamin C   (j) vitamin D 3      (k) a pharmaceutically-acceptable compound of calcium   (l) a pharmaceutically-acceptable compound of magnesium   (m) a pharmaceutically-acceptable compound of zinc   (n) a pharmaceutically-acceptable compound of selenium   (o) a pharmaceutically-acceptable compound of iron   (p) a pharmaceutically-acceptable compound of L-carnitine.   
     
     
         2 . The composition of  claim 1 , wherein the composition comprises
 (a) vitamin B1 in the amount of 0.1 mg to 50 mg per unit dose;   (b) vitamin B2 in the amount of 0.1 mg to 2 mg per unit dose;   (c) vitamin B3 in the amount of 1 mg to 40 mg per unit dose;   (d) vitamin B5 in the amount of 1 mg to 20 mg per unit dose;   (e) vitamin B6 in the amount of 1 mg to 100 mg per unit dose;   (f) vitamin B7 in the amount of 10 μg to 500 μg per unit dose;   (g) vitamin B9 in the amount of 0.05 mg to 1.0 mg per unit dose;   (h) vitamin B12 in the amount of 1 μg to 150 μg per unit dose;   (i) vitamin C in the amount of 10 mg to 2,000 mg per unit dose;   (j) vitamin D 3  in the amount of 1 μg to 100 μg per unit dose;   (k) a pharmaceutically-acceptable compound of calcium in the amount of 100 mg to 2,500 mg per unit dose;   (l) a pharmaceutically-acceptable compound of magnesium in the amount of 100 mg to 500 mg per unit dose;   (m) a pharmaceutically-acceptable compound of zinc in the amount of 1 mg to 40 mg per unit dose;   (n) a pharmaceutically-acceptable compound of selenium in the amount of 10 μg to 400 μg per unit dose;   (o) a pharmaceutically-acceptable compound of iron in the amount of 1 mg to 45 mg per unit dose;   (p) a pharmaceutically-acceptable compound of L-carnitine in the amount of 100 mg to 3,500 mg per unit dose.   
     
     
         3 . The composition of  claim 1 , wherein the pharmaceutically-acceptable compound of L-carnitine is L-carnitine-L-tartrate or acetyl-L-carnitine. 
     
     
         4 . The composition of  claim 1 , wherein the calcium is calcium citrate, the magnesium is magnesium citrate, the zinc is zinc citrate; the sodium is sodium selenate; and the iron is iron gluconate. 
     
     
         5 . The composition of  claim 1 , wherein the composition further comprises a citrus bioflavonoid, a powdered extract of cranberry and/or cherry, or a combination thereof. 
     
     
         6 . The composition of  claim 1 , wherein the composition comprises a dry powder. 
     
     
         7 . The composition of  claim 1 , wherein the composition comprises
 (a) vitamin B1 in the amount of 0.5 mg to 2 mg per unit dose;   (b) vitamin B2 in the amount of 0.5 mg to 2 mg per unit dose;   (c) vitamin B3 in the amount of 1 mg to 20 mg per unit dose;   (d) vitamin B5 in the amount of 1 mg to 15 mg per unit dose;   (e) vitamin B6 in the amount of 1 mg to 10 mg per unit dose;   (f) vitamin B7 in the amount of 10 g to 100 μg per unit dose;   (g) vitamin B9 in the amount of 0.1 mg to 1.0 mg per unit dose;   (h) vitamin B12 in the amount of 1 μg to 10 μg per unit dose;   (i) vitamin C in the amount of 100 mg to 300 mg per unit dose;   (j) vitamin D 3  in the amount of 1 μg to 20 μg per unit dose;   (k) a pharmaceutically-acceptable compound of calcium in the amount of 100 mg to 1,000 mg per unit dose;   (l) a pharmaceutically-acceptable compound of magnesium in the amount of 100 mg to 500 mg per unit dose;   (m) a pharmaceutically-acceptable compound of zinc in the amount of 5 mg to 20 mg per unit dose;   (n) a pharmaceutically-acceptable compound of selenium in the amount of 10 μg to 100 μg per unit dose;   (o) a pharmaceutically-acceptable compound of iron in the amount of 5 mg to 30 mg per unit dose; and   (p) L-carnitine-L-tartrate in the amount of 1,000 mg to 3,000 mg per unit dose.   
     
     
         8 . The composition of  claim 1 , wherein the composition does not include a pharmaceutically-acceptable compound of potassium, sodium, or phosphorous. 
     
     
         9 . A kit comprising
 (a) the composition of  claim 1 ; and   (b) a capsule comprising marine omega 3 fatty acids, a gel comprising coenzyme Q10, or a combination thereof.   
     
     
         10 . The kit of  claim 9 , wherein the marine omega 3 fatty acids comprise DHA and EPA in the weight ratio (EPA:DHA) of 1:1 to 4:1. 
     
     
         11 . The kit of  claim 9 , wherein the marine omega 3 fatty acids are in the amount of 500 mg to 4,000 mg per unit dose. 
     
     
         12 . The kit of  claim 9 , wherein coenzyme Q10 is ubiquinol. 
     
     
         13 . The kit of  claim 9 , wherein the coenzyme Q10 is in the amount of 70 mg to 400 mg per unit dose. 
     
     
         14 . The kit of  claim 9 , wherein the kit further comprises a capsule comprising turmeric, wherein the turmeric is in the amount of 1 g to 3 g per unit dose. 
     
     
         15 . The kit of  claim 9 , wherein the dry component in component (a) comprises
 (a) vitamin B1 in the amount of 0.1 mg to 50 mg per unit dose;   (b) vitamin B2 in the amount of 0.1 mg to 2 mg per unit dose;   (c) vitamin B3 in the amount of 1 mg to 40 mg per unit dose;   (d) vitamin B5 in the amount of 1 mg to 20 mg per unit dose;   (e) vitamin B6 in the amount of 1 mg to 100 mg per unit dose;   (f) vitamin B7 in the amount of 10 μg to 500 μg per unit dose;   (g) vitamin B9 in the amount of 0.05 mg to 1.0 mg per unit dose;   (h) vitamin B12 in the amount of 1 μg to 150 μg per unit dose;   (i) vitamin C in the amount of 10 mg to 2,000 mg per unit dose;   (j) vitamin D 3  in the amount of 1 μg to 100 μg per unit dose;   (k) a pharmaceutically-acceptable compound of calcium in the amount of 100 mg to 2,500 mg per unit dose;   (l) a pharmaceutically-acceptable compound of magnesium in the amount of 100 mg to 500 mg per unit dose;   (m) a pharmaceutically-acceptable compound of zinc in the amount of 1 mg to 40 mg per unit dose;   (n) a pharmaceutically-acceptable compound of selenium in the amount of 10 μg to 400 μg per unit dose;   (o) a pharmaceutically-acceptable compound of iron in the amount of 1 mg to 45 mg per unit dose;   (a) a pharmaceutically-acceptable compound of L-carnitine in the amount of 100 mg to 3,500 mg per unit dose.   
     
     
         16 . The kit of  claim 15 , wherein the pharmaceutically-acceptable compound of L-carnitine is L-carnitine-L-tartrate or acetyl-L-carnitine. 
     
     
         17 . The kit of  claim 15 , wherein the calcium is calcium citrate, the magnesium is magnesium citrate, the zinc is zinc citrate; the sodium is sodium selenate; and the iron is iron gluconate. 
     
     
         18 . The kit of  claim 15 , wherein the composition further comprises a citrus bioflavonoid, a powdered extract of cranberry and/or cherry, or a combination thereof. 
     
     
         19 . The kit of  claim 9 , wherein the dry component in component (a) comprises
 (a) vitamin B1 in the amount of 0.5 mg to 2 mg per unit dose;   (b) vitamin B2 in the amount of 0.5 mg to 2 mg per unit dose;   (c) vitamin B3 in the amount of 1 mg to 20 mg per unit dose;   (d) vitamin B5 in the amount of 1 mg to 15 mg per unit dose;   (e) vitamin B6 in the amount of 1 mg to 10 mg per unit dose;   (f) vitamin B7 in the amount of 10 g to 100 μg per unit dose;   (g) vitamin B9 in the amount of 0.1 mg to 1.0 mg per unit dose;   (h) vitamin B12 in the amount of 1 μg to 10 μg per unit dose;   (i) vitamin C in the amount of 100 mg to 300 mg per unit dose;   (j) vitamin D 3  in the amount of 1 μg to 20 μg per unit dose;   (k) a pharmaceutically-acceptable compound of calcium in the amount of 100 mg to 1,000 mg per unit dose;   (l) a pharmaceutically-acceptable compound of magnesium in the amount of 100 mg to 500 mg per unit dose;   (m) a pharmaceutically-acceptable compound of zinc in the amount of 5 mg to 20 mg per unit dose;   (n) a pharmaceutically-acceptable compound of selenium in the amount of 10 μg to 100 μg per unit dose;   (o) a pharmaceutically-acceptable compound of iron in the amount of 5 mg to 30 mg per unit dose; and   (a) L-carnitine-L-tartrate in the amount of 1,000 mg to 3,000 mg per unit dose.   
     
     
         20 . The kit of  claim 9 , wherein the dry powder in component (a) does not include a pharmaceutically-acceptable compound of potassium, sodium, or phosphorous.