System and method for early detection of post-surgery infection

Abstract

In-vivo systems and methods for the detection of early signs of post-surgery infection are described. The in-vivo systems include a drain system with a tube configured to drain fluids from a surgery site, at least one sensor unit for sensing the presence of at least one infection biomarker, a processor for processing a signal generated by the at least one sensor unit, a transmitter for transmitting the signal, and a notification system for receiving the signal, analyzing the signal by comparing it to a threshold, determining presence of infection, and generating an indication on the presence of infection.

1 - 23 . (canceled) 
     
     
         24 . A system for detecting early signs of post-surgery infection in a patient, the system comprising:
 a drain system comprising a tube configured to drain fluids from a surgery site;   at least one sensor unit configured for sensing a presence of at least one infection biomarker selected from lactic acid, immune-modulating mediators, pancreas enzymes, inflammatory parameters, metabolic parameters, or combinations thereof, the at least one sensor unit located within the tube;   a processor configured for processing a signal generated by the at least one sensor unit;   a transmitter configured for transmitting the signal; and   a notification system configured for receiving the signal, analyzing the signal by comparing the signal to a threshold, determining presence of an infection, and generating an indication on the presence of the infection.   
     
     
         25 . The system according to  claim 24 , wherein the at least one sensor unit comprises a memory unit. 
     
     
         26 . The system according to  claim 24 , wherein the at least one sensor unit comprises a heating resistor for controlling a temperature within the at least one sensor unit. 
     
     
         27 . The system according to  claim 24 , wherein the at least one sensor unit comprises an illumination source and a photodetector. 
     
     
         28 . The system according to  claim 27 , wherein the at least one sensor unit further comprises a sol-gel material located between the illumination source and the photodetector. 
     
     
         29 . The system according to  claim 24 , wherein the at least one sensor unit comprises at least a first sensor unit and a second sensor unit. 
     
     
         30 . The system according to  claim 24 , wherein the at least one infection biomarker is an immune-modulating mediator selected from IL-1, IL-6, IL-10, TNF-a, or combinations thereof. 
     
     
         31 . The system according to  claim 24 , wherein the at least one infection biomarker is a pancreas enzyme including amylase. 
     
     
         32 . The system according to  claim 24 , wherein the at least one infection biomarker is an inflammatory parameter including Lipopolysaccharide Binding Protein. 
     
     
         33 . The system according to  claim 24 , wherein the at least one infection biomarker is a metabolic parameter including glucose. 
     
     
         34 . The system according to  claim 24 , wherein the at least one infection biomarker includes lactic acid, IL-6, glucose, or combinations thereof. 
     
     
         35 . The system according to  claim 24 , further comprising a suction element for drawing the fluids from the surgery site through the tube. 
     
     
         36 . The system according to  claim 24 , wherein the system further comprises another sensor unit configured for sensing at least a second infection biomarker selected from  Escherischia coli, Pseudomonas  spp.,  Pseudomonas aeruginosa, Pseudomonas putida, Staphylococcus  spp.,  Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus  spp.,  Enterococcus  spp.,  Klebsiella  spp.,  Proteus  spp.,  Serratia  spp.,  Morganella  spp.,  Enterobacteriaceae , or combinations thereof. 
     
     
         37 . The system according to  claim 36 , wherein the notification system comprises an analyzer for analyzing signals detected by the at least one sensor unit and the another sensor unit and determining presence of the infection. 
     
     
         38 . The system according to  claim 24 , wherein the notification system comprises an analyzer for analyzing a processed signal and determining presence of the infection. 
     
     
         39 . The system according to  claim 38 , wherein the analyzer further determines a stage of the infection. 
     
     
         40 . The system according to  claim 24 , wherein the indication is displayed on a display unit. 
     
     
         41 . The system according to  claim 24 , wherein the at least one sensor unit senses the presence of the at least one infection biomarker continuously. 
     
     
         42 . The system according to  claim 24 , wherein the at least one sensor unit senses the presence of the at least one infection biomarker periodically. 
     
     
         43 . A system for detecting early signs of post-surgery infection in a patient, the system comprising:
 a drain system comprising a tube configured to drain fluids from a surgery site;   at least one sensor unit configured for sensing a presence of at least one infection biomarker selected from lactic acid, IL-6, glucose, or combinations thereof, the at least one sensor unit located within the tube;   a processor configured for processing a signal generated by the at least one sensor unit;   a transmitter configured for transmitting the signal; and   a notification system configured for receiving the signal, analyzing the signal by comparing the signal to a threshold, determining presence of an infection, and generating an indication on the presence of the infection.