US2021348190A1PendingUtilityA1
Adeno-associated virus (aav) serotype 8 sequences, vectors containing same, and uses therefor
Est. expiryDec 17, 2021(expired)· nominal 20-yr term from priority
C12N 2750/14122A61P 7/04A61K 35/761C12N 2830/48A61K 38/177A61P 11/00A61P 43/00A61K 38/4846C12N 2830/85C07K 14/755C12N 9/644C12N 9/1018A61P 1/18C12N 2830/008C12Y 304/21022C12Y 304/21021C12N 2750/14143C07K 14/005A61K 38/45C12N 15/86A61P 31/20C12Y 201/03003C12N 15/8645A61K 48/00C12N 7/00C12N 2750/14152C07K 14/705A61K 9/0019
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Claims
Abstract
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.
Claims
exact text as granted — not AI-modified1 . An adeno-associated virus (AAV)8 viral vector comprising an AAV8 capsid having packaged therein a heterologous gene operably linked to regulatory sequences which direct its expression, wherein the AAV8 capsid comprises a vp3 capsid protein having the sequence of aa 203 to 737 of SEQ ID NO: 2, or a sequence which is at least 95% identical to said sequence of aa 203 to 737 of SEQ ID NO: 2.
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