Pouches

Abstract

The present invention relates to apertured pouches comprising a fibrous matrix containing a bioactive ingredient, including kits, methods of use and methods of manufacture.

We claim: 
     
         1 . A pouch for administration of a bioactive ingredient, comprising a fibrous matrix material incorporating a plurality of apertures defining a sealed pouch, and a bioactive ingredient containing fill material positioned within the sealed pouch, and wherein the pouch is adapted to release between 40% to 90% of the bioactive ingredient present in the fill material in under 15 minutes after being placed in a mouth of a user. 
     
     
         2 . The pouch for administration of a bioactive ingredient of  claim 1 , wherein the bioactive ingredient is a cannabinoid, a terpene; kava root, including different forms, derivatives and extracts therefrom, such as those including a kavalactone; chili pepper, including different forms, derivatives and extracts therefrom, such as those including capsicum; kanna/sceletium tortuosum, including different forms, derivatives and extracts therefrom; yerba mate, including different forms, derivatives and extracts therefrom such as those derived from the holly genus ilex; guayusa, including different forms, derivatives and extracts therefrom; kratom, including different forms, derivatives and extracts therefrom such as those derived from mitragyna speciosa; mushroom, including different forms, derivatives and extracts therefrom such as those including psilocybin and extracts thereof; melatonin, including different forms, derivatives and extracts therefrom; spilanthes acmela, including derivatives and extracts therefrom; coenzyme-Q10; pyrroloquinoline quinone, including different forms, derivatives and extracts therefrom; nicotinamide riboside, including different forms, derivatives and extracts cobalamins therefrom; ascorbic acid, including different forms, derivatives and extracts therefrom; cobalamins, including different forms, derivatives and extracts therefrom; pyridoxal-5-phosphate, including different forms, derivatives and extracts therefrom; 1-theanine, including different forms, derivatives and extracts therefrom; caffeine, including different forms, derivatives and extracts therefrom; Rhodiola rosea, including different forms, derivatives and extracts therefrom; choline, including different forms, derivatives and extracts therefrom; pine pollen extract, including different forms, derivatives and extracts therefrom; deer antler velvet, including different forms, derivatives and extracts therefrom; gingko biloba, including different forms, derivatives and extracts therefrom; vinpocetine, including different forms, derivatives and extracts therefrom; bacopa monnieri, including different forms, derivatives and extracts therefrom; ganoderman lucidium, including different forms, derivatives and extracts therefrom; cordyceps sinesis, including different forms, derivatives and extracts therefrom; hericium erinaceus, including different forms, derivatives and extracts therefrom; creatine monohydrate, including different forms, derivatives and extracts therefrom; branched chain amino acids, including different forms, derivatives and extracts therefrom; guarana seed, including different forms, derivatives and extracts therefrom; panax ginseng root, including different forms, derivatives and extracts therefrom; sibering ginseng root, including different forms, derivatives and extracts therefrom; ashwaghanda, including different forms, derivatives and extracts therefrom; astralagus, including different forms, derivatives and extracts therefrom; curcurmin, including different forms, derivatives and extracts therefrom; maca, including different forms, derivatives and extracts therefrom; holy basil, including different forms, derivatives and extracts therefrom; schisandra, including different forms, derivatives and extracts therefrom; tongkat ali, including different forms, derivatives and extracts therefrom; gamma aminobutyric acid, including different forms, derivatives and extracts therefrom; tribulus terrestris, including different forms, derivatives and extracts therefrom; or a combination of two or more of the foregoing. 
     
     
         3 . The pouch for administration of a bioactive ingredient of  claim 2 , wherein the bioactive ingredient is a cannabinoid. 
     
     
         4 . The pouch for administration of a bioactive ingredient of  claim 3 , further comprising a terpene in the fill material. 
     
     
         5 . The pouch for administration of a bioactive ingredient of  claim 2 , wherein each of the plurality of apertures is defined by an aperture size of between about 400 μm to about 800 μm in diameter. 
     
     
         6 . The pouch for administration of a bioactive ingredient of  claim 2 , wherein each of the plurality of apertures is defined by an aperture size of above about 400 μm in diameter. 
     
     
         7 . The pouch for administration of a bioactive ingredient of  claim 2 , wherein the pouch is adapted to release between 40% to 90% of the bioactive ingredient present in the fill material in between 5 to 10 minutes after being placed in a mouth of a user. 
     
     
         8 . The pouch for administration of a bioactive ingredient of  claim 5 , wherein at least about 50% of the plurality of apertures have the identified size. 
     
     
         9 . The pouch for administration of a bioactive ingredient of  claim 5 , wherein at least about 90% of the plurality of apertures have the identified size. 
     
     
         10 . The pouch for administration of a bioactive ingredient of  claim 2 , wherein the each of the plurality of apertures is circular in shape. 
     
     
         11 . The pouch for administration of a bioactive ingredient of  claim 1 , wherein the cannabinoid containing fill material comprises cannabidiol, coconut coir, a terpene, a natural oil, a sweetener, a stabilizer and a flavorant. 
     
     
         12 . The pouch for administration of a bioactive ingredient of  claim 11 , wherein the coconut coir is comprised of coconut coir particles having a mean size range of between about 800 μm to at or about 900 μm. 
     
     
         13 . The pouch for administration of a bioactive ingredient of  claim 1 , wherein the cannabinoid containing fill material comprises water dispersible cannabidiol and/or cannabidiol isolate. 
     
     
         14 . The pouch for administration of a bioactive ingredient of  claim 2 , wherein the plurality of apertures comprise holes extending through the fibrous matrix material. 
     
     
         15 . The pouch for administration of a bioactive ingredient of  claim 2 , wherein the bioactive ingredient containing fill material comprises an electrospun nanofiber, wherein the electrospun nanofiber comprises cannabidiol. 
     
     
         16 . The pouch for administration of a bioactive ingredient of  claim 1 , wherein the bioactive ingredient containing fill material comprises a cannabinoid selected from the group consisting of one or more of cannabidiol (CBD); cannabinol; cannabigerol; cannabichromene; cannabidivarol; tetrahydrocannabidiol; tetrahydrocannabigerol; tetrahydrocannabichromene; tetrahydrocannabidivarol; Δ 8 -THC, and carboxylic acid precursors of the foregoing. 
     
     
         17 . The pouch for administration of a bioactive ingredient of  claim 14 , wherein the bioactive ingredient containing fill material further comprises a terpene selected from the group consisting of one or more of bomeol, caryophyllene, cineole/eucalyptol, delta3carene, limonene, linolool, myrcene, pinene, pulegone, d-limonene linalool, 1,8-cineole (eucalyptol), terpineol-4-ol, p-cymene, Δ-3-carene, β-sitosterol, or β-caryophyllene.cannflavin A, apigenin, and quercetin. 
     
     
         18 . The pouch for administration of a bioactive ingredient of  claim 2 , wherein the bioactive ingredient containing fill material comprises a blended composition having a total weight, and bioactive ingredient containing fill material includes the bioactive ingredient between about 5% to at or about 20% of the total weight. 
     
     
         19 . The pouch for administration of a bioactive ingredient of  claim 2 , wherein the fibrous matrix material is selected from one or more of coconut coir, kenaf, abaca, flax, hemp, jute, ramie, sisal, rice, bamboo, corn husk, silk husk, fruit skin, straw, soy, mint leaf, spearmint leaf, lettuce leaf, synthetic fibers, animal-derived fibers, chitin, and kudzu root. 
     
     
         20 . A pouch for administration of a bioactive, comprising a fibrous matrix material incorporating a plurality of apertures defining a sealed pouch, and a bioactive ingredient containing fill material positioned within the sealed pouch, wherein
 the bioactive ingredient containing fill material comprises a cannabinoid, a terpene; kava root, including different forms, derivatives and extracts therefrom, such as those including a kavalactone; chili pepper, including different forms, derivatives and extracts therefrom, such as those including capsicum; kanna/sceletium tortuosum, including different forms, derivatives and extracts therefrom; yerba mate, including different forms, derivatives and extracts therefrom such as those derived from the holly genus ilex; guayusa, including different forms, derivatives and extracts therefrom; kratom, including different forms, derivatives and extracts therefrom such as those derived from mitragyna speciosa; mushroom, including different forms, derivatives and extracts therefrom such as those including psilocybin and extracts thereof; melatonin, including different forms, derivatives and extracts therefrom; spilanthes acmela, including derivatives and extracts therefrom; coenzyme-Q10; pyrroloquinoline quinone, including different forms, derivatives and extracts therefrom; nicotinamide riboside, including different forms, derivatives and extracts therefrom; ascorbic acid, including different forms, derivatives and extracts therefrom; cobalamins, including different forms, derivatives and extracts therefrom; pyndoxal-5-phosphate, including different forms, derivatives and extracts therefrom; l-theanine, including different forms, derivatives and extracts therefrom; caffeine, including different forms, derivatives and extracts therefrom; rhodiola rosca, including different forms, derivatives and extracts therefrom; choline, including different forms, derivatives and extracts therefrom; pine pollen extract, including different forms, derivatives and extracts therefrom; deer antler velvet, including different forms, derivatives and extracts therefrom; gingko biloba, including different forms, derivatives and extracts therefrom; vinpocetine, including different forms, derivatives and extracts therefrom; bacopa monnieri, including different forms, derivatives and extracts therefrom; ganoderman lucidium, including different forms, derivatives and extracts therefrom; cordyceps sinesis, including different forms, derivatives and extracts therefrom; hericium erinaceus, including different forms, derivatives and extracts therefrom; creatine monohydrate, including different forms, derivatives and extracts therefrom; branched chain amino acids, including different forms, derivatives and extracts therefrom; guarana seed, including different forms, derivatives and extracts therefrom; panax ginseng root, including different forms, derivatives and extracts therefrom; sibering ginseng root, including different forms, derivatives and extracts therefrom; ashwaghanda, including different forms, derivatives and extracts therefrom; astralagus, including different forms, derivatives and extracts therefrom; curcurmin, including different forms, derivatives and extracts therefrom; maca, including different forms, derivatives and extracts therefrom; holy basil, including different forms, derivatives and extracts therefrom; schisandra, including different forms, derivatives and extracts therefrom; tongkat ali, including different forms, derivatives and extracts therefrom; gamma aminobutyric acid, including different forms, derivatives and extracts therefrom; tribulus terrestris, including different forms, derivatives and extracts therefrom; or a combination of two or more of the foregoing;   the fibrous matrix material selected from one or more of coconut coir, kenaf, abaca, flax, hemp, jute, ramie, sisal, rice, bamboo, corn husk, silk husk, fruit skin, straw, soy, mint leaf, spearmint leaf, lettuce leaf, synthetic fibers, animal-derived fibers, chitin, and kudzu root;   the bioactive ingredient containing fill material further comprises one or more of a natural oil, a sweetener, a stabilizer, or a flavorant; and   wherein the pouch is adapted to release between 40% to 90% of the bioactive ingredient present in the fill material in under 15 minutes after being placed in a mouth of a user.