US2021322506A1PendingUtilityA1

Treating dry eye disorders

50
Assignee: YUNNAN BAIAOTAIKE BIOTECHNOLOGY CO LTDPriority: Jan 8, 2019Filed: Jan 8, 2020Published: Oct 21, 2021
Est. expiryJan 8, 2039(~12.4 yrs left)· nominal 20-yr term from priority
Inventors:Dan Yang
A61K 36/287A61K 2236/00A61K 47/46A61K 47/44A61K 9/0048A61P 27/02A61K 36/889A61K 36/482A61K 36/481A61K 31/045A61K 38/13A61K 36/815A61K 2236/50
50
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

This disclosure is related to compositions and methods for treating dry dye disorders.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of treating a dry eye disorder or alleviating symptoms of a dry eye disorder, comprising
 administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising deacidified coconut oil.   
     
     
         2 . The method of  claim 1 , wherein the dry eye disorder is dry eye syndrome. 
     
     
         3 . The method of  claim 1  or  2 , wherein the composition is administered to the patient's eye as an eye drop. 
     
     
         4 . The method of any one of  claims 1 - 3 , wherein the composition consists essentially of deacidified coconut oil. 
     
     
         5 . The method of any one of  claims 1 - 4 , wherein the deacidified coconut oil administered to the patient is made by a process comprising the following steps:
 providing coconut oil;   mixing the coconut oil with a basic solution (pH>8), thereby obtaining a mixture comprising a water phase and an oil phase;   separating the water phase and the oil phase from the mixture; and   collecting deacidified coconut oil from the oil phase.   
     
     
         6 . The method of  claim 5 , wherein the process further comprises:
 mixing coconut meat or coconut powder with a base, thereby obtaining a coconut meat mixture;   heating and pressing the coconut meat mixture, thereby obtaining an extract; and   collecting coconut oil from the extract.   
     
     
         7 . The method of any one of  claims 1 - 6 , wherein prior to administering the pharmaceutical composition to the subject, artificial tear eye drops are administered to the subject. 
     
     
         8 . The method of any one of  claims 1 - 7 , wherein the method further comprises orally administering to the subject an effective amount of a composition comprising one, two, or all of the following ingredients:
 (1) wolfberries ( Lycium barbarum  or  Lycium chinense ) or a wolfberry extract;   (2)  Astragalus  root or an  Astragalus  root extract;   (3)  chrysanthemum  or a  chrysanthemum  extract to the subject.   
     
     
         9 . The method of  claim 8 , wherein the method comprises
 orally administering an effective amount of wolfberries ( Lycium barbarum  or  Lycium chinense ) or a wolfberry extract to the subject.   
     
     
         10 . The method of  claim 8 , wherein the method further comprises
 orally administering an effective amount of  Astragalus  root or an  Astragalus  root extract to the subject.   
     
     
         11 . The method of  claim 8 , wherein the method further comprises
 orally administering an effective amount of  chrysanthemum  or a  chrysanthemum  extract to the subject.   
     
     
         12 . The method of any one of  claims 1 - 11 , wherein the method further comprises
 administering a heat therapy to the eye of the subject.   
     
     
         13 . The method of  claim 12 , wherein the heat therapy comprises
 applying a thermal pad comprising a herb composition on the eye of the subject.   
     
     
         14 . The method of  claim 12  or  13 , wherein the herb composition comprises  Cassiae  semen and borneol. 
     
     
         15 . The method of  claim 14 , wherein the weight percentage of  Cassiae  semen in the herb composition is from 50% to 90%. 
     
     
         16 . The method of  claim 14 , wherein the weight percentage of borneol in the herb composition is from 10% to 50%. 
     
     
         17 . A pharmaceutical composition comprising deacidified coconut oil. 
     
     
         18 . The composition of  claim 17 , wherein the pharmaceutical composition consists of deacidified coconut oil. 
     
     
         19 . The method of  claim 17  or  18 , wherein the deacidified coconut oil is made by a process comprising the following steps:
 providing coconut oil; 
 mixing the coconut oil with a basic solution (pH>8), thereby obtaining a mixture comprising a water phase and an oil phase; 
 separating the water phase and the oil phase from the mixture; and 
 collecting deacidified coconut oil from the oil phase. 
 
     
     
         20 . The method of  claim 19 , wherein the process further comprises:
 mixing coconut meat or coconut powder with a base, thereby obtaining a coconut meat mixture;   heating and pressing the coconut meat mixture, thereby obtaining an extract; and   collecting coconut oil from the extract.   
     
     
         21 . A method of improving the efficacy of an artificial tear eye drops in a subject, the method comprising
 administering an artificial tear eye drop to the subject; and   administering to the subject an effective amount of a composition comprising deacidified coconut oil after the artificial tear eye drop is administered to the subject.   
     
     
         22 . The method of  claim 21 , wherein the composition consists essentially of deacidified coconut oil. 
     
     
         23 . The method of  claim 21  or  22 , wherein the composition comprising deacidified coconut oil is administered within 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 minutes after the artificial tear eye drop is administered to the subject. 
     
     
         24 . A herb composition comprising:
 (1) wolfberries ( Lycium barbarum  or  Lycium chinense ) or a wolfberry extract;   (2)  Astragalus  root or an  Astragalus  root extract; and   (3)  chrysanthemum  or a  chrysanthemum  extract.   
     
     
         25 . The herb composition of  claim 24 , wherein the ratio of (1), (2), and (3) is about 1:1:1. 
     
     
         26 . A thermal pad comprising a herb composition, wherein the herb composition comprises  Cassiae  semen and borneol. 
     
     
         27 . The thermal pad of  claim 26 , wherein the weight percentage of  Cassiae  semen in the herb composition is from 50% to 90%. 
     
     
         28 . The thermal pad of  claim 26 , wherein the weight percentage of borneol in the herb composition is from 10% to 50%. 
     
     
         29 . A method of making a composition comprising deacidified coconut oil, the method comprising:
 mixing coconut meat or coconut powder with a base or a basic solution, thereby obtaining a coconut meat mixture;   heating and pressing the coconut meat mixture, thereby obtaining an extract; and   collecting the coconut oil from the extract.   
     
     
         30 . The method of  claim 29 , wherein the method further comprises:
 after collecting coconut oil from the extract, mixing the coconut oil with a basic solution (pH>7), thereby obtaining a mixture comprising a water phase and an oil phase;   separating the water phase and the oil phase from the mixture; and   collecting deacidified coconut oil from the oil phase.   
     
     
         31 . The method of  claim 31 , wherein the method further comprises:
 filtering the deacidified coconut oil through membrane filtration, thereby obtaining a filtered deacidified coconut oil; and   sterilizing the filtered deacidified coconut oil.   
     
     
         32 . A method of making a composition comprising deacidified coconut oil, the method comprising:
 mixing coconut oil with a base or a basic solution, thereby obtaining a mixture; and   collecting deacidified coconut oil.   
     
     
         33 . The method of  claim 32 , wherein the method comprises
 mixing coconut oil with a basic solution;   separating the water phase and the oil phase from the mixture; and   collecting deacidified coconut oil.   
     
     
         34 . The method of  claim 33 , wherein the method further comprises:
 filtering the deacidified coconut oil through membrane filtration, thereby obtaining a filtered deacidified coconut oil; and   sterilizing the filtered deacidified coconut oil.   
     
     
         35 . A composition comprising deacidified coconut oil and cyclosporine. 
     
     
         36 . The composition of  claim 35 , wherein cyclosporine has a concentration of 0.05%. 
     
     
         37 . A method of treating a dry eye disorder or alleviating symptoms of a dry eye disorder, comprising
 administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising deacidified coconut oil and cyclosporine.   
     
     
         38 . The method of anyone of  claims 1 - 14 , further comprising administering an effective amount of cyclosporine to the subject.

Join the waitlist — get patent alerts

Track US2021322506A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.