US2021315871A1PendingUtilityA1

Methods for treating aortic valve stenosis with a hedgehog pathway inhibitor

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Assignee: UNIV INDIANA TRUSTEESPriority: Jun 29, 2018Filed: Jun 22, 2021Published: Oct 14, 2021
Est. expiryJun 29, 2038(~11.9 yrs left)· nominal 20-yr term from priority
Inventors:Jingwu Xie
A61K 39/3955A61K 31/437A61K 31/4365A61K 31/395A61P 11/00A61K 31/166A61B 8/0883A61B 5/329A61B 5/0205A61K 31/444A61K 31/502A61K 31/454A61K 31/517A61K 31/505A61K 31/496A61K 31/58A61K 31/4402A61K 31/5377A61P 9/10A61P 1/16A61K 33/36C07K 16/18A61B 5/318
66
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Claims

Abstract

Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.

Claims

exact text as granted — not AI-modified
1 . A method of treating a valvular heart disease in a subject, the method comprising:
 administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.   
     
     
         2 .- 22 . (canceled)

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