US2021308337A1PendingUtilityA1

Compositions and methods for enhancing healing and regeneration of bone and soft tissue

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Assignee: SWEETBIO INCPriority: Aug 5, 2014Filed: Apr 14, 2021Published: Oct 7, 2021
Est. expiryAug 5, 2034(~8 yrs left)· nominal 20-yr term from priority
Inventors:Isaac Anthony RodriguezGary BowlinBrenton Walter Burger
A61L 2300/412A61L 27/222A61L 2300/406A61L 27/54A61L 27/58A61L 2300/404A61L 27/365A61L 27/12A61L 27/56A61L 27/46A61L 27/26A61L 27/3604A61L 27/18A61L 2430/02A61L 27/48A61P 17/00A61L 27/24A61L 2300/30A61P 19/00
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Claims

Abstract

The invention features biodegradable materials, and in vitro and in vivo methods of using such compositions to promote bone and soft tissue growth and healing.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition, comprising:
 honey; and   one or more biodegradable polymers,   wherein the composition is in a surgically-implantable form, and   wherein the composition promotes tissue regeneration when surgically implanted in contact with a tissue in a subject.   
     
     
         2 . The composition of  claim 1 , wherein the composition is provided as a solid, a membrane, a multi-layer membrane, or a particulate. 
     
     
         3 . The composition of  claim 1 , wherein the composition is degradable in vivo. 
     
     
         4 . The composition of  claim 1 , wherein the honey comprises methylglyoxal. 
     
     
         5 . The composition of  claim 1 , wherein the one of more biodegradable polymers comprise at least one natural polymer. 
     
     
         6 . The composition of  claim 5 , wherein the at least one natural polymer comprises collagen or gelatin. 
     
     
         7 . The composition of  claim 1 , wherein the one of more biodegradable polymers comprise at least one synthetic polymer. 
     
     
         8 . The composition of  claim 7 , wherein the at least one synthetic polymer is selected from the group consisting of; a poly(urethane), a poly(siloxane) or a silicone, a poly(ethylene), poly(vinyl pyrrolidone), poly(2-hydroxy ethyl methacrylate), poly(N-vinyl pyrrolidone), poly(methyl methacrylate), poly(vinyl alcohol), poly(acrylic acid), polyacrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polylactic acid (PLA), polyglycolic acids (PGA), poly(lactide-co-glycolides) (PLGA), polydioxanone (PDO), a nylon, a polyamide, a polyanhydride, poly(ethylene-co-vinyl alcohol) (EVOH), polycaprolactone, poly(vinyl acetate) (PVA), polyvinylhydroxide, poly(ethylene oxide) (PEO), polyorthoesters PEA, a copolymer of PLA, PGA, PLGA, PDO, or PEO, and combinations thereof. 
     
     
         9 . The composition of  claim 7 , wherein the one or more biodegradable polymers comprise at least one natural polymer comprising collagen or gelatin. 
     
     
         10 . The composition of  claim 1 , wherein the honey is present in an amount of from 1 part to 300 parts by weight relative to 100 parts by weight of the one or more biodegradable polymers. 
     
     
         11 . A multi-layer membrane, comprising:
 a first layer including one or more biodegradable polymers;   a second layer including one or more biodegradable polymers; and   honey in at least one of the first layer or the second layer.   
     
     
         12 . The multi-layer membrane of  claim 11 , wherein at least one of the first layer or the second layer is cross-linked. 
     
     
         13 . The multi-layer membrane of  claim 11 , wherein the one or more biodegradable polymers of the first layer comprise a natural biodegradable polymer. 
     
     
         14 . The multi-layer membrane of  claim 13 , wherein the natural biodegradable polymer comprises collagen or gelatin. 
     
     
         15 . The multi-layer membrane of  claim 11 , wherein the one or more biodegradable polymers of the second layer comprises at least one synthetic biodegradable polymer. 
     
     
         16 . The multi-layer membrane of  claim 15 , wherein the synthetic biodegradable polymer is selected from the group consisting of: a poly(urethane), a poly(siloxane) or a silicone, a poly(ethylene), poly(vinyl pyrrolidone), poly(2-hydroxy ethyl methacrylate), poly(N-vinyl pyrrolidone), poly(methyl methacrylate), poly(vinyl alcohol), poly(acrylic acid), poly acrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polylactic acid (PLA), polyglycolic acids (PGA), poly(lactide-co-glycolides) (PLGA), polydioxanone (PDO), a nylon, a polyamide, a polyanhydride, poly(ethylene-co-vinyl alcohol) (EVOH), polycaprolactone, poly(vinyl acetate) (PVA), polyvinylhydroxide, poly(ethylene oxide) (PEO), polyorthoesters PEA, a copolymer of PLA, PGA, PLGA, PDO, or PEO, and combinations thereof. 
     
     
         17 . The multi-layer membrane of  claim 11 , further comprising a third layer including one or more biodegradable polymers and the honey, wherein the second layer is disposed between the first layer and the third layer. 
     
     
         18 . The multi-layer membrane of  claim 11 , wherein the layer comprising honey promotes tissue regeneration when surgically implanted in contact with a tissue in a subject. 
     
     
         19 . The multi-layer membrane of  claim 11 , wherein the honey comprises methylglyoxal. 
     
     
         20 . The multi-layer membrane of  claim 11 , wherein the honey is present in the first layer or the second layer an amount of from 1 part to 300 parts by weight relative to 100 parts by weight of the one or more biodegradable polymers in the first layer or the second layer, respectively. 
     
     
         21 . A method of promoting tissue regeneration in vivo in a subject, the method comprising:
 providing a composition, the composition including honey and one or more biodegradable polymers; and   implanting the composition in contact with tissue in the subject through a surgical site of the subject,   wherein the composition promotes tissue regeneration in the tissue when contacted with the tissue.   
     
     
         22 . The method of  claim 21 , wherein the composition is provided in solid form. 
     
     
         23 . The method of  claim 21 , wherein the composition is provided as a membrane, a multi-layer membrane, or a particulate. 
     
     
         24 . The method of  claim 21 , wherein the one of more biodegradable polymers comprise at least one natural polymer. 
     
     
         25 . The method of  claim 24 , wherein the at least one natural polymer comprises collagen or gelatin. 
     
     
         26 . The method of  claim 21 , wherein the one of more biodegradable polymers comprise at least one synthetic polymer. 
     
     
         27 . The method of  claim 26 , wherein the at least one synthetic polymer is selected from the group consisting of: a poly(urethane), a poly(siloxane) or a silicone, a poly(ethylene), poly(vinyl pyrrolidone), poly(2-hydroxy ethyl methacrylate), poly(N-vinyl pyrrolidone), poly(methyl methacrylate), poly(vinyl alcohol), poly(acrylic acid), polyacrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polylactic acid (PLA), polyglycolic acids (PGA), poly(lactide-co-glycolides) (PLGA), polydioxanone (PDO), a nylon, a polyamide, a polyanhydride, poly(ethylene-co-vinyl alcohol) (EVOH), polycaprolactone, poly(vinyl acetate) (PVA), polyvinylhydroxide, poly(ethylene oxide) (PEO), polyorthoesters PEA, a copolymer of PLA, PGA, PLGA, PDO, or PEO, and combinations thereof. 
     
     
         28 . The method of  claim 26 , wherein the one or more biodegradable polymers comprise at least one natural polymer comprising collagen or gelatin. 
     
     
         29 . The method of  claim 21 , wherein the honey is present in an amount of from 1 part to 300 parts by weight relative to 100 parts by weight of the one or more biodegradable polymers. 
     
     
         30 . The method of  claim 29 , wherein the honey comprises methylglyoxal.

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