US2021308026A1PendingUtilityA1

Topical compositions for reducing the effects of aging

56
Assignee: SAMSON PHARMA LLCPriority: Mar 15, 2013Filed: Jan 7, 2021Published: Oct 7, 2021
Est. expiryMar 15, 2033(~6.6 yrs left)· nominal 20-yr term from priority
Inventors:Manzer Durrani
A61K 8/9771A61K 2800/805A61K 8/34A61K 2800/596A61K 2800/49A61K 8/86A61Q 19/08A61K 8/8152A61K 2800/52A61K 8/365A61K 8/062A61K 8/42A61K 2800/522A61K 8/347A61K 2800/75A61K 8/37A61K 8/368A61P 17/00A61K 8/19
56
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Claims

Abstract

The present invention comprises ternary compositions of tamibarotene and/or ammonium lactate in Pemulen for treatment of effects of aging.

Claims

exact text as granted — not AI-modified
1 - 25 . (canceled) 
     
     
         26 . A topical composition for reducing the effects of aging comprising tamibarotene in a cosmetically acceptable carrier, wherein the carrier comprises an emulsifier of an acrylates/C10-30 alkyl acrylate crosspolymer. 
     
     
         27 . The topical composition of  claim 26 , wherein the carrier comprises a stable oil in water emulsion. 
     
     
         28 . The topical composition of  claim 26 , wherein the effects of aging are selected from increase in skin roughness, loss of skin elasticity, increase in skin transparency, skin fragility, increased frequency of bruising, macroscopic appearance of skin wrinkles and folds, and skin discoloration. 
     
     
         29 . The topical composition of  claim 26 , wherein the acrylates/C10-30 alkyl acrylate crosspolymer is a Pemulen™ emulsifier. 
     
     
         30 . The topical composition of  claim 29 , wherein the Pemulen™ emulsifier is Pemulen™ TR-1 or Pemulen™ TR-2. 
     
     
         31 . The topical composition of  claim 26 , wherein the composition further comprises ammonium lactate. 
     
     
         32 . The topical composition of  claim 31 , wherein the ammonium lactate is present in the composition in an amount between about 17 to 20 weight percent. 
     
     
         33 . The topical composition of  claim 26 , wherein the composition is a cream. 
     
     
         34 . The topical composition of  claim 26 , wherein the composition is a gel. 
     
     
         35 . A method for reducing the effects of aging comprising:
 applying to the skin a topical formulation of tamibarotene in a cosmetically acceptable carrier, wherein the carrier comprises an emulsifier of an acrylates/C10-30 alkyl acrylate crosspolymer.   
     
     
         36 . The method of  claim 35 , wherein the carrier comprises a stable oil in water emulsion. 
     
     
         37 . The method of  claim 35 , wherein the effects of aging are selected from increase in skin roughness, loss of skin elasticity, increase in skin transparency, skin fragility, increased frequency of bruising, macroscopic appearance of skin wrinkles and folds, and skin discoloration. 
     
     
         38 . The method of  claim 35 , wherein the acrylates/C10-30 alkyl acrylate crosspolymer is a Pemulen™ emulsifier. 
     
     
         39 . The method of  claim 38 , wherein the Pemulen™ emulsifier is Pemulen™ TR-1 or Pemulen™ TR-2. 
     
     
         40 . The method of  claim 35 , wherein the composition further comprises ammonium lactate. 
     
     
         41 . The method of  claim 40 , wherein the ammonium lactate is present in the composition in an amount between about 17 to 20 weight percent. 
     
     
         42 . The method of  claim 35 , wherein the composition is a cream. 
     
     
         43 . The method of  claim 35 , wherein the composition is a gel. 
     
     
         44 . A topical composition comprising tamibarotene in a cosmetically acceptable carrier, wherein the carrier comprises an emulsifier of an acrylates/C10-30 alkyl acrylate crosspolymer. 
     
     
         45 . The topical composition of  claim 44 , wherein the carrier comprises a stable oil in water emulsion. 
     
     
         46 . The topical composition of  claim 44 , wherein the topical composition reduces acne. 
     
     
         47 . The method of  claim 44 , wherein the method treats eczema, psoriasis, wrinkles or dry skin. 
     
     
         48 . The topical composition of  claim 44 , wherein the acrylates/C10-30 alkyl acrylate crosspolymer is a Pemulen™ emulsifier. 
     
     
         49 . The topical composition of  claim 48 , wherein the Pemulen™ emulsifier is Pemulen™ TR-1 or Pemulen™ TR-2. 
     
     
         50 . The composition of  claim 44 , wherein the composition further comprises ammonium lactate. 
     
     
         51 . The composition of  claim 50 , wherein the ammonium lactate is present in the composition in an amount between about 17 to 20 weight percent. 
     
     
         52 . The composition of  claim 44 , wherein the composition is a cream. 
     
     
         53 . The composition of  claim 44 , wherein the composition is a gel. 
     
     
         54 . A method for treating skin comprising:
 applying to the skin a topical formulation of tamibarotene in a cosmetically acceptable carrier, wherein the carrier comprises an emulsifier of an acrylates/C10-30 alkyl acrylate crosspolymer.   
     
     
         55 . The topical composition of  claim 54 , wherein the carrier comprises a stable oil in water emulsion. 
     
     
         56 . The method of  claim 54 , wherein the method reduces acne. 
     
     
         57 . The method of  claim 54 , wherein the method treats eczema, psoriasis, wrinkles, or dry skin. 
     
     
         58 . The method of  claim 54 , wherein the acrylates/C10-30 alkyl acrylate crosspolymer is a Pemulen™ emulsifier. 
     
     
         59 . The method of  claim 58 , wherein the Pemulen™ emulsifier is Pemulen™ TR-1 or Pemulen™ TR-2. 
     
     
         60 . The method of  claim 54 , wherein the composition further comprises ammonium lactate. 
     
     
         61 . The method of  claim 60 , wherein the ammonium lactate is present in the composition in an amount between about 17 to 20 weight percent. 
     
     
         62 . The method of  claim 54 , wherein the composition is a cream. 
     
     
         63 . The method of  claim 54 , wherein the composition is a gel. 
     
     
         64 . A topical formulation of ammonium lactate in a carrier comprising an acrylates/C10-30 alkyl acrylate crosspolymer. 
     
     
         65 . The topical formulation of  claim 64 , wherein the formulation is oil in water (o/w) emulsion. 
     
     
         66 . The topical formulation of  claim 64 , wherein the ammonium lactate is present from about 17 to about 20 percent by weight. 
     
     
         67 . The topical formulation of  claim 64 , wherein the formulation further comprises an anti-irritant and/or a retinoid.

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