Risk of allergy and nutrition to reduce that risk

Abstract

A method to predict the risk of eczema is provided based on differences in the development of microbiota and its metabolites in healthy infants and infants that develop eczema, and nutritional remedies based on this finding, in the form of lactate utilizing bacteria and fibres stimulating lactate utilizing bacteria.

1 . A nutritional composition, comprising lactate utilizing bacteria and at least one fibre selected from the group consisting of polyfructose with an average degree of polymerisation (DP) of 10 or higher, polydextrose with an average DP of 10 or higher and partially hydrolysed guar gum with an average DP of 10 or higher. 
     
     
         2 . The nutritional composition according to  claim 1 , wherein the lactate utilizing bacteria are selected from the group consisting of  Anaerostipes  and  Eubacterium.    
     
     
         3 . The nutritional composition according to  claim 1 , wherein the lactate utilizing bacteria are selected from the group consisting of  Anaerostipes caccae, Anaerostipes butyraticus, Anaerostipes hadrus, Anaerostipes rhamnosivorans, E hallii  and  E. limosum.    
     
     
         4 . The nutritional composition according to  claim 1 , wherein the lactate utilizing bacteria comprise  Anaerostipes caccae.    
     
     
         5 . The nutritional composition according to  claim 1 , wherein the amount of lactate utilizing bacteria is 10 2  to 10 9  cfu per g dry weight. 
     
     
         6 . The nutritional composition according to  claim 1 , wherein the fibre comprises partially hydrolysed guar gum. 
     
     
         7 . The nutritional composition according to  claim 6 , wherein the partially hydrolysed guar gum has a DP between 10 and 300. 
     
     
         8 . The nutritional composition according to  claim 1 , wherein the fibre comprises polyfructose. 
     
     
         9 . The nutritional composition according to  claim 8 , wherein the polyfructose has an average DP between 10 and 300. 
     
     
         10 . The nutritional composition according to  claim 8 , wherein the polyfructose is inulin. 
     
     
         11 . The nutritional composition according to  claim 1 , wherein the fibre comprises polydextrose. 
     
     
         12 . The nutritional composition according to  claim 8 , wherein the polydextrose has a DP of 10 to 50. 
     
     
         13 . The nutritional composition according  claim 8 , wherein the amount of fibre is 0.2 to 8 g per 100 g dry weight. 
     
     
         14 . The nutritional composition according to  claim 1 , which further comprises protein, fat and carbohydrates, wherein the protein provides 5 to 16% of the total calories, the fat provides 35 to 60% of the total calories and the carbohydrates provide 25 to 75% of the total calories. 
     
     
         15 . The nutritional composition according to  claim 14 , wherein the protein provides 5 to 12% of the total calories, the fat provides 39 to 50% of the total calories and the carbohydrates provide 40 to 55% of the total calories. 
     
     
         16 . The nutritional composition according to  claim 1 , which is a follow on formula or young child formula. 
     
     
         17 . A method of preventing allergy or reducing the risk of allergy in an infant or young child comprising administering to the infant or young child a nutritional composition. 
     
     
         18 . A method of preventing allergy or reducing the risk of allergy in an infant or young child, comprising administering to the infant or young child the nutritional composition according to  claim 1 .