Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor

Abstract

Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.

1 . A protein comprising an AAV9/HU.14 protein or a fragment thereof selected from the group consisting of:
 (a) an AAV9/HU.14 capsid protein or fragment thereof, selected from the group consisting of:
 vp1 capsid protein, amino acids (aa) 1 to 736, SEQ ID NO:123; 
 vp2 capsid protein, aa 138 to 736, SEQ ID NO: 123; 
 vp3 capsid protein, aa 203 to 736, SEQ ID NO: 123; 
 wherein the amino acid numbers are those of the AAV2 capsid, SEQ ID NO:4 and corresponding regions in the capsid of AAV9/HU.14, SEQ ID NO:123.