Topical composition for use in the treatment of burns

Abstract

The present disclosure relates to topical compositions for the treatment or prophylaxis of burns. The topical compositions comprise water, solvent, thickener, preservative and conditioning agent, and are exposed to gamma radiation. One embodiment of the topical compositions includes water, propanediol, sodium acryloyldimethyltaurate/VP crosspolymer, a combination of phenoxyethanol and caprylyl glycol and chlorphenesin, polyaminopropyl biguanide (PHMB) and a mineral complex. The present disclosure also relates to the use of the topical compositions with a dressing and the use of the topical compositions and dressings in treatment or prophylaxis of burns.

1 . A topical composition comprising:
 water, in a range of approximately 85-95% w/w of the composition;   propanediol, in a range of approximately 5-10% w/w of the composition;   sodium acryloyldimethyltaurate/VP crosspolymer, in a range of approximately 0.5-1.0% w/w of the composition;   one or more preservatives, in a range of approximately 0.5-2.0% w/w of the composition; and   a mineral complex, in a range of approximately 0.1-1.0% w/w of the composition.   
     
     
         2 . The topical composition of  claim 1 , wherein the one or more preservatives is selected from the group consisting of polyaminopropyl biguanide (PHMB) and a combination of phenoxyethanol and caprylyl glycol and chlorphenesin. 
     
     
         3 . The topical composition of  claim 1 , wherein the composition has a viscosity approximately in the range 200-6000 cP at 25° C. following exposure to gamma radiation. 
     
     
         4 . The topical composition of  claim 1 , wherein the water is selected from the group consisting of tap water, purified water, sterile water and halogenated water. 
     
     
         5 . The topical composition of  claim 1  wherein the mineral complex is sea water extract. 
     
     
         6 . The topical composition of  claim 1  wherein the mineral complex comprises magnesium, potassium, sodium, boron and calcium. 
     
     
         7 . The topical composition of  claim 6  wherein the mineral complex further comprises one or more from the group consisting of: copper, nickel, silicon, zinc, aluminium, arsenic, barium, cadmium, cobalt, chromium, iron, mercury, manganese, lead, antimony, selenium, tin, strontium, titanium and vanadium. 
     
     
         8 . The topical composition of  claim 1 , wherein the composition has a specific gravity of approximately 1.000±0.05 at 25° C. 
     
     
         9 . The topical composition of  claim 1 , wherein the composition has a pH approximately in the range 4.0-6.5 at 25° C. 
     
     
         10 . A burn dressing comprising the topical composition of  claim 1  and a dressing material. 
     
     
         11 . A method of sterilising a topical composition of  claim 1  comprising applying gamma radiation of approximately 25.0 to 44.5 kGy to the composition. 
     
     
         12 . The composition of  claim 1  which has been sterilised using the method of  claim 1 . 
     
     
         13 . A method of prophylaxis or treatment of a burn comprising the step of applying the topical composition of  claim 1  to skin in need thereof. 
     
     
         14 . The burn dressing according to  claim 10  which has been sterilised using the method of  claim 11 . 
     
     
         15 . A method of prophylaxis or treatment of a burn comprising the step of applying a burn dressing according to  claim 10  to skin in need thereof. 
     
     
         16 . A topical composition consisting of:
 water, in a range of approximately 85-95% w/w of the composition;   propanediol, in a range of approximately 5-10% w/w of the composition;   sodium acryloyldimethyltaurate/VP crosspolymer, in a range of approximately 0.5-1.0% w/w of the composition;   a combination of phenoxyethanol and caprylyl glycol and chlorphenesin, in a range of approximately 0.5-1.5% w/w of the composition;   polyaminopropyl biguanide (PHMB), in a range of approximately 0.05-0.15% w/w of the composition; and   a mineral complex, in a range of approximately 0.1-1.0% w/w of the composition.   
     
     
         17 . The topical composition of  claim 16 , wherein the composition has a viscosity approximately in the range 200-6000 cP at 25° C. following exposure to gamma radiation of approximately 25.0 to 44.5 kGy. 
     
     
         18 . A burn dressing comprising the topical composition of  claim 16  and a dressing material. 
     
     
         19 . A method of prophylaxis or treatment of a burn comprising the step of applying the topical composition of  claim 16  to skin in need thereof. 
     
     
         20 . The topical composition according to  claim 16 , wherein the mineral complex comprises magnesium, potassium, sodium, boron, calcium and optionally one or more from the group consisting: copper, nickel, silicon, zinc, aluminium, arsenic, barium, cadmium, cobalt, chromium, iron, mercury, manganese, lead, antimony, selenium, tin, strontium, titanium and vanadium.