Multiple layer devices for treatment of vascular defects

Abstract

Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a first permeable shell and a second permeable shell, where the second permeable shell sits within an interior cavity of the first permeable shell. The first and second permeable shells may each be made from a plurality of elongate filaments that are woven together to form a mesh. The mesh of the first permeable shell may have a larger mesh density and be softer than the mesh of the second permeable shell.

1 . A device for treatment of a patient's cerebral aneurysm, comprising:
 a first permeable shell having a proximal end, a distal end, a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form a mesh, the expanded state defining an interior cavity; and   a second permeable shell having a proximal end, a distal end, a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form a mesh,   wherein the second permeable shell sits within the interior cavity of the first permeable shell, and wherein the first and second permeable shells each have an average mesh density, and wherein the average mesh density of the second permeable shell is smaller than the average mesh density of the first permeable shell.   
     
     
         2 . The device of  claim 1 , wherein each of the plurality of filaments forming the first permeable shell has a proximal and distal end, wherein the proximal ends of the plurality of filaments of the first permeable shell are gathered in a proximal marker band. 
     
     
         3 . The device of  claim 2 , wherein each of the plurality of filaments forming the second permeable shell has a proximal and distal end, wherein the proximal ends of the plurality of filaments of the second permeable shell are gathered in the proximal marker band. 
     
     
         4 . The device of  claim 2 , wherein the distal ends of the plurality of filaments forming the first permeable shell are gathered in a first distal marker band. 
     
     
         5 . The device of  claim 3 , wherein the distal ends of the plurality of filaments forming the second permeable shell are gathered in a second distal marker band. 
     
     
         6 . The device of  claim 1 , wherein the mesh of the first permeable shell has a different braid angle than the mesh of the second permeable shell. 
     
     
         7 . The device of  claim 1 , wherein the mesh of the first permeable shell is softer than the mesh of the second permeable shell. 
     
     
         8 . The device of  claim 1 , wherein a height of the expanded state of the second permeable shell is less than a height of the expanded state of the first permeable shell. 
     
     
         9 . The device of  claim 1 , wherein a height of the expanded state of the second permeable shell is substantially the same as a height of the expanded state of the first permeable shell. 
     
     
         10 . The device of  claim 1 , wherein each of the wires of the plurality of wires of the first permeable shell has a diameter between about 0.0005″ and about 0.00075″. 
     
     
         11 . The device of  claim 1 , wherein each of the wires of the plurality of wires of the second permeable shell has a diameter between about 0.00125″ and about 0.002″. 
     
     
         12 . The device of  claim 1 , wherein the first permeable shell is made from about 108 filaments or more. 
     
     
         13 . The device of  claim 1 , wherein the second permeable shell is made from between about 18 and 48 filaments. 
     
     
         14 . The device of  claim 1 , wherein the plurality of filaments forming the second permeable shell have a larger diameter than the plurality of filaments forming the first permeable shell. 
     
     
         15 . The device of  claim 1 , wherein a smaller number of filaments form the second permeable shell than the first permeable shell. 
     
     
         16 . The device of  claim 1 , wherein the first and second permeable shells each have an average pore size, and wherein the average pore size of the second permeable shell is larger than the average pore size of the first permeable shell. 
     
     
         17 . The device of  claim 16 , wherein the average pore size of the second permeable shell is between about 150 microns and about 1 mm. 
     
     
         18 . The device of  claim 16 , wherein the average pore size of the first permeable shell is between about 100 microns and about 400 microns. 
     
     
         19 . The device of  claim 16 , wherein the average pore size of the second permeable shell is at least about 2 greater than the average pore size of the first permeable shell. 
     
     
         20 . The device of  claim 1 , wherein the average mesh density of the second permeable shell is at least about 2 smaller than the average mesh density of the first permeable shell. 
     
     
         21 - 44 . (canceled)