US2021277487A1PendingUtilityA1

Detection of colorectal cancer

Assignee: UNIVERSAL DIAGNOSTICS S LPriority: May 31, 2019Filed: May 25, 2021Published: Sep 9, 2021

Est. expiryMay 31, 2039(~12.8 yrs left)· nominal 20-yr term from priority

Inventors:Marko Bitenc Kristi Kruusmaa Juan Martinez-Barea Christian Hense Marko Chersicola Primo{Hacek Over (Z)} Knap

C12Q 2600/154C12Q 2600/112C12Q 1/6886C12Q 1/686

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References

Claims

Abstract

The present disclosure provides, among other things, methods for colorectal cancer screening and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR.

Claims

exact text as granted — not AI-modified

1 .- 30 . (canceled) 
     
     
         31 . A kit for use in colorectal cancer screening, the kit comprising:
 at least one oligonucleotide primer pair for amplification of a methylation locus within a differentially methylated region (DMR) of one or more of the genes according to Table 13.   
     
     
         32 . (canceled) 
     
     
         33 . The kit of  claim 31 , wherein the oligonucleotide primer pairs include oligonucleotide primer pairs for amplification of DMRs ZNF471 &#39;558 and FGF14 &#39;577. 
     
     
         34 . The kit of  claim 31 , wherein the oligonucleotide primer pairs include oligonucleotide primer pairs for amplification of DMRs ZNF471 &#39;558, FGF14 &#39;577, and PDGFD ‘388. 
     
     
         35 . The kit of  claim 31 , wherein the oligonucleotide primer pairs include oligonucleotide primer pairs for amplification of DMRs ZNF471 &#39;558, FGF14 &#39;577, PDGFD ‘388, ZNF471 &#39;527, and ADAMTS2 &#39;284. 
     
     
         36 . The kit of  claim 31 , wherein the oligonucleotide primer pairs include oligonucleotide primer pairs for amplification of DMRs ZNF471 &#39;558, FGF14 &#39;577, PDGFD ‘388, ZNF471 &#39;527, ADAMTS2 &#39;284, ADAMTS2 &#39;254, ZNF492 &#39;069, and ST6GALNAC5 &#39;456. 
     
     
         37 . The kit of  claim 31 , wherein the oligonucleotide primer pairs include oligonucleotide primer pairs for amplification of DMRs ZNF471 &#39;558, FGF14 &#39;577, PDGFD ‘388, ZNF471 &#39;527, ADAMTS2 &#39;284, ADAMTS2 &#39;254, ZNF492 &#39;069, ST6GALNAC5 &#39;456, ZNF542 &#39;502, LONRF2 &#39;281, ZNF132 &#39;415, PDGFD ‘921, ZNF132 &#39;268, CNRIP1 &#39;272, and ALK ‘434. 
     
     
         38 .- 41 . (canceled)

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