Nutritional Treatment for Cancer

Abstract

Methods of screening cancerous cells for nutritional weaknesses and methods of treating cancer nutritionally are disclosed. Certain cancers depend on being supplied with one or more nutrients that are non-essential for normal cells. In particular, the invention relates to methods of treating cancer by identifying nutritional weaknesses of cancer cells and using nutritional therapy to suppress cancer by putting a subject on a diet that deprives cancerous cells of a nutrient needed for cancer proliferation and growth. Nutritional therapy can be used to enhance the effectiveness of current cancer treatments.

1 .- 20 . (canceled) 
     
     
         21 . A method for reducing or eliminating a subject's daily intake of cysteine or cystine, the method comprising subjecting the subject to a low-cysteine diet that reduces the subject's daily intake of cysteine or cystine in food by at least 50%. 
     
     
         22 . The method of  claim 21 , wherein the low-cysteine diet comprises methionine. 
     
     
         23 . The method of  claim 21 , wherein the low-cysteine diet comprises all essential amino acids including histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. 
     
     
         24 . The method of  claim 21 , wherein the low-cysteine diet comprises all essential amino acids including histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine at levels in accordance with United States Recommended Daily Allowances (USRDA) guidelines. 
     
     
         25 . The method of  claim 21 , further comprising reducing or eliminating the subject's daily intake of at least one amino acid selected from the group consisting of arginine, glutamine, serine, and tyrosine. 
     
     
         26 . The method of  claim 21 , wherein said subjecting comprises placing said subject on said low-cysteine diet for at least one month. 
     
     
         27 . The method of  claim 21 , wherein the method is in combination with surgery, radiation therapy, chemotherapy, hormonal therapy, immunotherapy, biologic therapy, or a combination thereof. 
     
     
         28 . The method of  claim 21 , further comprising administering to the subject one or more therapeutic agents selected from the group consisting of a cysteine/cystine-depleting drug, a cysteine degradation enzyme, a gamma-glutamyl transpeptidase inhibitor, a cysteine/cystine transporter inhibitor, and an inhibitor of cysteine biosynthesis. 
     
     
         29 . The method of  claim 21 , wherein a cancer is responsive to the low-cysteine diet. 
     
     
         30 . The method of  claim 29 , wherein the cancer is lung cancer, liver cancer, breast cancer, prostate cancer, colon cancer, pancreatic cancer, head cancer, neck cancer, lymphoma, or leukemia, or a combination thereof. 
     
     
         31 . The method of  claim 21 , wherein said subject is on said low-cysteine diet until at least a partial tumor response is effected. 
     
     
         32 . The method of  claim 21 , wherein said subject is a mammal or a human. 
     
     
         33 . The method of  claim 21 , wherein the low-cysteine diet does not comprise cysteine. 
     
     
         34 . A meal characterized in that:
 (a) it comprises all essential amino acids including histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine; and   (b) it comprises no more than 50% of cysteine or cystine as compared to a corresponding reference; and   (c) it is a breakfast meal, a lunch meal, a dinner meal, or a snack.   
     
     
         35 . The meal of  claim 34 , wherein the meal is a pre-packaged meal. 
     
     
         36 . The meal of  claim 34 , wherein the meal is a cysteine-free meal. 
     
     
         37 . The meal of  claim 34 , further comprising a low amount of at least one amino acid selected from the group consisting of arginine, glutamine, serine, and tyrosine. 
     
     
         38 . The meal of  claim 34 , wherein the meal does not contain at least one amino acid selected from the group consisting of arginine, glutamine, serine, and tyrosine. 
     
     
         39 . The meal of  claim 34 , wherein the meal is a protein-free meal or low-protein meal. 
     
     
         40 . The meal of  claim 34 , wherein the meal comprises all essential amino acids including histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine at levels in accordance with United States Recommended Daily Allowances (USRDA) guidelines.