Crystalline form of cyclosporin a, methods of preparation, and methods for use thereof

Abstract

The present invention relates generally to crystalline forms of cyclosporin A and particularly to a newly identified form of cyclosporin A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.

What is claimed is: 
     
         1 . A crystalline form of cyclosporin A having an X-ray powder diffraction pattern with major peaks at about (2θ): 7.5, 8.8, 10.2, 11.3, 12.7, 13.8, 14.5, 15.6 and 17.5, substantially free of other crystalline forms of cyclosporin A. 
     
     
         2 . A crystalline form of cyclosporin A having the X-ray diffraction pattern substantially as shown in  FIG. 2 , substantially free of other crystalline forms of cyclosporin A. 
     
     
         4 . A crystalline form as set forth by the formula: 
       
         
           
           
               
               
           
         
         wherein X is 2 and wherein the crystalline form is substantially free of other crystalline forms of cyclosporin A.