US2021267897A1PendingUtilityA1
Therapeutic Nanoparticles and Related Compositions, Methods and Systems
Est. expirySep 3, 2034(~8.1 yrs left)· nominal 20-yr term from priority
Inventors:Gretchen M. Unger
A61P 35/00A61K 31/7088A61K 9/1075A61K 9/5161A61K 9/5169A61K 9/141A61K 48/00C12N 15/88
64
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Claims
Abstract
Disclosed are targeted sub-50 nanometer nanoparticles suitable for delivering bioactive agents of interest, and related compositions, methods, and systems, which improve the manufacturing, stability, efficacy and other aspects of therapeutic nanoparticles.
Claims
exact text as granted — not AI-modified1 . A composition comprising nanoparticles, wherein the nanoparticles comprise: at least one bioactive agent, a surfactant having an hydrophile-lipophile balance (HLB) value of less than 6.0 units, a ligand, and Li+ and Cs+, wherein: i) the at least one bioactive agent and the surfactant form a surfactant micelle core; ii) the ligand forms a shell which substantially coats the nanoparticles; and iii) the nanoparticles have an average diameter of less than about 50 nanometers.
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