Derivatives of porphyrins, their process of preparation and their use for treating viral infections

Abstract

The present invention concerns metallated porphyrin derivatives as ligands of G-quadruplex and their novel use as anti-viral agents.

What is claimed is: 
     
         1 . A compound of formula (IA): 
       
         
           
           
               
               
           
         
         wherein: 
         in Formula (IA) - - - represents an optionally present single bond; 
         M represents H 2 , Cobalt (Co), Manganese (Mn) or a Nickel (Ni) atom; 
         A −  represents a counter anion; and 
       
       
         
           
           
               
               
           
         
       
       wherein - - - represents the attachment of X to the phenyl groups in Formula (IA). 
     
     
         2 . The compound according to  claim 1  wherein X represents 
       
         
           
           
               
               
           
         
       
       and M represents a Manganese atom. 
     
     
         3 . The compound of formula (IA) according to  claim 1 , wherein A −  represents a halogen ion. 
     
     
         4 . The compound according to  claim 1 , wherein A −  is Cl − . 
     
     
         5 . A pharmaceutical composition comprising the compound according to  claim 1 , and at least one pharmaceutically acceptable excipient. 
     
     
         6 . A process for the preparation of the compound according to  claim 1  comprising reacting a compound of formula (II) 
       
         
           
           
               
               
           
         
         wherein X is defined as in  claim 1 , and wherein B −  represents a counter anion; 
         with a gold-containing complex. 
       
     
     
         7 . The process according to  claim 6  wherein the counter anion is trifluoroacetate. 
     
     
         8 . The process according to  claim 6  wherein the gold-containing complex is a complex of formula (III):
   KAu III A 4   (III)
 
 wherein A represents a counter anion.