US2021252152A1PendingUtilityA1
Near-infrared (nir) absorbing photosensitizers
Est. expiryJun 25, 2038(~11.9 yrs left)· nominal 20-yr term from priority
A61K 49/0021A61K 41/0057C07F 17/02C07F 9/6584A61P 35/00C07F 7/0814C07F 5/022C07F 7/0816
52
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Claims
Abstract
Near-infrared (NIR) absorbing photosensitizers for imaging and treatment of cancer in a photodynamic therapy (PDT) are provided. Specifically, the NIR photosensitizers are mitochondria targeted and water-soluble, and used as a cytotoxic drug in a photodynamic therapy of the cancer. The NIR photosensitizers are activated with wavelengths of light, wherein the light penetrates through a body not just a skin. Hence the NIR photosensitizers aim to transform PDT from being a specialized treatment to a generally applicable one. PDT is almost completely non-invasive compared to current treatment methods.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . A near-infrared (NIR) absorbing photosensitizer, comprising formula A or B;
wherein,
wherein,
R 7 =alkyl and aryl derivatives;
R 8 =H, Br, I, any alkyl and aryl derivatives;
R 9 =H, Br, I, any alkyl and aryl derivatives;
R 10 =H, Br, I, any alkyl and aryl derivatives;
R 11 =H, Br, I, any other possible alkyl and aryl derivatives;
R 12 =H, Br, I, any other possible alkyl and aryl derivatives;
R 13 =H, Br, I, any other possible alkyl and aryl derivatives;
R 14 =H, Br, I, any other possible alkyl and aryl derivatives; and
R 15 =H, Br, I, any other possible alkyl and aryl derivatives;
wherein,
R 7 =alkyl and aryl derivatives;
R 8 =H, Br, I, any alkyl and aryl derivatives;
R 9 =H, Br, I, any alkyl and aryl derivatives;
R 10 =H, Br, I, any alkyl and aryl derivatives;
R 11 =H, Br, I, any other possible alkyl and aryl derivatives;
R 12 =H Br, I, any other possible alkyl and aryl derivatives;
R 13 =H, Br, I, any other possible alkyl and aryl derivatives;
R 14 =H, Br, I, any other possible alkyl and aryl derivatives; and
R 15 =H, Br, I, any other possible alkyl and aryl derivatives.
2 . The NIR absorbing photosensitizer according to claim 1 , comprising one selected from the group of
3 . A NIR absorbing photosensitizer, comprising formula C or D or E or F or G or H:
wherein:
wherein
R 3 =alkyl and aryl derivatives;
R 4 =—H, —Br, —I, alkyl and aryl derivatives;
R 5 =—H, —Br, —I, alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 = H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 ==—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 11 =—H, —Br, —I, an other possible alkyl and aryl derivatives;
wherein
R 3 =alkyl and aryl derivatives;
R 4 =—H, —Br, —I, alkyl and aryl derivatives;
R 5 =—H, —Br, —I, alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 11 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
wherein:
wherein
R 3 =alkyl and aryl derivatives;
R 4 =alkyl and aryl derivatives;
R 5 =alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 11 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 12 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 13 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
wherein
R 5 alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 11 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 12 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 13 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
wherein;
wherein
R 3 =alkyl and aryl derivatives;
R 4 =alkyl and aryl derivatives;
R 5 =alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 —H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 11 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 12 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 13 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
wherein
R 5 =alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 11 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 12 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 13 =—H, —Br, —I, any other possible alkyl, and aryl derivatives;
wherein;
wherein
R 2 =alkyl and aryl derivatives;
R 3 =—H, —Br, —I, alkyl and aryl derivatives;
R 4 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 5 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 6 —H, —Br, —I, any other possible alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives
wherein
R 2 =alkyl and aryl derivatives;
R 3 =—H, —Br, —I, alkyl and aryl derivatives;
R 4 =—Br, —I, any other possible alkyl and aryl derivatives;
R 5 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 6 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
wherein;
wherein
R 3 =alkyl and aryl derivatives;
R 4 =alkyl and aryl derivatives;
R 5 =—H, —Br, —I, alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 11 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 12 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
wherein
R 4 =alkyl and aryl derivatives;
R 5 =—H, —Br, —I, alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 11 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 12 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
wherein;
wherein
R 3 =alkyl and aryl derivatives;
R 4 =alkyl and aryl derivatives;
R 5 =—H, —Br, —I, alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 11 =—H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 12 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
wherein
R 4 =alkyl and aryl derivatives;
R 5 =—H, —Br, —I, alkyl and aryl derivatives;
R 6 =—H, —Br, —I, alkyl and aryl derivatives;
R 7 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 8 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 9 =—H, —Br, —I, any other possible alkyl and aryl derivatives;
R 10 =H, —Br, —I, any other possible alkyl and aryl derivatives;
R 11 =H, —Br, —I, any other possible alkyl and aryl derivatives; and
R 12 =H, —Br, —I, any other possible alkyl and aryl derivatives.
4 . The NIR absorbing photosensitizer according to claim 3 , comprising one selected from the group of
5 . The NIR absorbing photosensitizer according to claim 1 , wherein the NIR absorbing photosensitizer is mitochondria targeted.
6 . The NIR absorbing photosensitizer according to claim 1 , wherein the NIR absorbing photosensitizer is water-soluble.
7 . A method of using the compounds according to claim 1 , wherein the compounds are used as a cytotoxic drug in a photodynamic therapy of a cancer.
8 . The NIR absorbing photosensitizer according to claim 1 , comprising formula I or J or K or L or M or N:
wherein;
wherein;
wherein:
wherein;
wherein:
wherein;
9 . The NIR absorbing photosensitizer according to claim 8 , comprising one selected from the group of
10 . A method of using the compounds for an imaging of cancer cells according to claim 9 .
11 . The NIR absorbing photosensitizer according to claim 2 , wherein the NIR absorbing photosensitizer is mitochondria targeted.
12 . The NIR absorbing photosensitizer according to claim 3 , wherein the NIR absorbing photosensitizer is mitochondria targeted.
13 . The NIR absorbing photosensitizer according to claim 4 , wherein the NIR absorbing photosensitizer is mitochondria targeted.
14 . The NIR absorbing photosensitizer according to claim 2 , wherein the NIR absorbing photosensitizer is water-soluble.
15 . The NIR absorbing photosensitizer according to claim 3 , wherein the NIR absorbing photosensitizer is water-soluble.
16 . The NIR absorbing photosensitizer according to claim 4 , wherein the NIR absorbing photosensitizer is water-soluble.Join the waitlist — get patent alerts
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