Anti-rds compounds and method of manufacture and administration thereof to induce dopamine homeostasis

Abstract

Compounds for treating reward deficiency syndrome (RDS) behaviors and methods of use and administration of such compounds to induce dopamine homeostasis are disclosed. These compounds synergistically combine two or more of (a) DPA, (b) NAC, and (c) kyotorphin (or arginine and tyrosine, the precursors of kyotorphin). These work together to enhance dopamine release by employing mechanisms tied to GABA regulation on Dorsal Raphe VGlut3 neurons via the Substania Nigra and increasing enkephalins (by increasing the release of enkepahlins and by the inhibition of enkephalinase). The resulting compound can induce dopamine homeostasis (and thus induce anti-stress states and diminish stress induced addictive behaviors). In some embodiments, the compound further includes nano-sized particles that enable the compound to be water- or powder-based even though DPA, NAC, and kyotorphin are not soluble in water.

What is claimed is: 
     
         1 . A composition comprising:
 a. a first nanoparticle substance selected from the group consisting of
 i. nanoparticle kyotorphin and 
 ii. a combination of nanoparticle arginine and nanoparticle tyrosine; and 
   b. a second nanoparticle substance comprising at least one of
 i. nanoparticle DPA and 
 ii. nanoparticle NAC, 
   wherein the composition is operable to induce dopamine homeostasis.   
     
     
         2 . The composition of  claim 1 , wherein the composition comprises the kyotorphin, the DPA, and the NAC. 
     
     
         3 . The composition of  claim 1 , wherein (a) the kyotorphin comprises D-kyotorphin, (b) the combination of arginine and tyrosine comprises a combination of L-arginine and L-tyrosine, and (c) the DPA is DLPA. 
     
     
         4 . The composition of  claim 1 , wherein (a) the combination of arginine and tyrosine comprises a combination of DL-arginine and DL-tyrosine, and (b) the DPA is DLPA. 
     
     
         5 . The composition of  claim 1 , wherein the composition is in tablet form. 
     
     
         6 . The composition of  claim 1 , wherein the composition is in liquid form. 
     
     
         7 . The composition of  claim 1 , wherein (a) the first nanoparticle substance is selected from the group consisting of (i) nanoparticle kyotorphin in a kyotorphin amount in the range of 0.1 to 5,000 mg and (ii) a combination of nanoparticle arginine and nanoparticle tyrosine, wherein the arginine is in an arginine amount in the range of 0.1 to 1,000 grams and the tyrosine is in a tyrosine amount in the range of 0.1 to 5,000 grams; and (b) the second nanoparticle substance comprises at least one of (i) the nanoparticle DPA in a DPA amount in the range of 1 to 5.000 mg, and (ii) the nanoparticle NAC in an NAC amount in the range of 1 to 10,000 mg. 
     
     
         8 . The composition of  claim 7 , wherein (a) the kyotorphin comprises D-kyotorphin, (b) the combination of arginine and tyrosine comprises a combination of L-arginine and L-tyrosine, and (c) the DPA is DLPA. 
     
     
         9 . The composition of  claim 8 , wherein (i) the DPA amount is 1,000 mg, (ii) the NAC amount is 2,400 mg, (iii) the kyotorphin amount is 500 mg, (iv) the arginine amount is 250 mg, and (v) the tyrosine amount is 150 mg. 
     
     
         10 . The composition of  claim 7 , wherein (a) the combination of arginine and tyrosine comprises a combination of DL-arginine and DL-tyrosine, and (b) the DPA is DLPA. 
     
     
         11 . The composition of  claim 1  further comprising an additional nanoparticle substance, wherein the additional nanoparticle substance is selected from the group consisting of pyridoxal-5-phoshate, L-glutamine,  Rhodiola rosea  root SE, rosavin, Griffonia seed extract 5-HTP, L chromium GTF plus, passion flower SE isovitexin, glucosamine n-acetyl, arabinogalactan fiberaid AG99, aloe vera FD powder 200.times., white birch bark extract,  Boswellia serrata  gum extract, and  Spirulina  algae. 
     
     
         12 . The composition of  claim 1 , wherein the first nanoparticle substance are nanoparticles having sizes in the range of 3 to 20 nm and the second nanoparticle substance are nanoparticles having sizes in the range of 3 to 20 nm. 
     
     
         13 . The composition of  claim 12 , wherein the first nanoparticle substance are spherical nanoparticles and the second nanoparticle substance are spherical nanoparticles.