US2021244694A1PendingUtilityA1

BHB-Citrate Combination Products for Renal Health and Treating Disease

Assignee: UNIV CALIFORNIAPriority: Mar 14, 2019Filed: Apr 26, 2021Published: Aug 12, 2021

Est. expiryMar 14, 2039(~12.6 yrs left)· nominal 20-yr term from priority

A61K 31/455A61K 31/225A61K 31/19A61P 31/20A61P 31/22A61P 31/16A61P 31/14A61P 31/12A61K 31/194A61K 31/047A61P 13/12A23L 33/20A23L 33/10

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Claims

Abstract

Compositions and methods for supporting health, especially renal health, comprising ketonic agents that recapitulate beneficial effects of ketosis by exogenously administered agents. The agents include BHB, analogs thereof, and GPR109A agonists. The agents may further include crystal precipitation inhibitors which synergistically improve treatment of certain renal conditions. The agents may be used in dietary supplements and therapeutic compositions for the treatment of cystic kidney diseases such as polycystic kidney disease, ciliopathies, and other conditions.

Claims

exact text as granted — not AI-modified

What is claimed is: 
     
         1 . A composition, comprising a mixture of:
 citrate; and   BHB and/or BHB analog;   wherein the weight percentage of citrate is at least about 20%, calculated as the proportional mass of citrate to the combined mass of BHB and/or BHB analog and citrate.   
     
     
         2 . The composition of  claim 1 ,
 wherein the BHB and/or BHB analog comprises BHB.   
     
     
         3 . The composition of  claim 1 ,
 wherein the BHB and/or BHB analog comprises a BHB analog.   
     
     
         4 . The composition of  claim 1 , wherein
 the weight percentage of citrate is in the range of about 35% to about 45%.   
     
     
         5 . The composition of  claim 1 , wherein
 the weight percentage of citrate is about 40%.   
     
     
         6 . The composition of  claim 1 , wherein
 the composition is formulated as a powder to be dissolved in liquid.   
     
     
         7 . The composition of  claim 1 , wherein
 the composition is provided in a dosage form comprising:
 at least about 1.0 g citrate; and 
 about 2.0-3.0 g BHB. 
   
     
     
         8 . The composition of  claim 1 , wherein
 the composition is formulated as infused water, a sports drink, an energy drink, tea, fruit juice, or a meal replacement beverage.   
     
     
         9 . The composition of  claim 1 , wherein
 the composition is formulated as a food item.   
     
     
         10 . The composition of  claim 1 , wherein
 the food item is formulated for non-human animals and comprises chow, feed, a treat or snack, or supplemented pet food.   
     
     
         11 . The composition of  claim 1 , wherein
 the composition is formulated as a dietary supplement.

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