Biomarkers for the Identification of Prostate Cancer and Methods of Use

Abstract

The present disclosure provides biomarkers for the identification of prostate cancer and methods of use. The present disclosure also provide biomarkers that can be used for determining risk of developing prostate cancer, aggressiveness of prostate cancer and survival rate for subpopulations of African American males or non-Hispanic white males.

We claim: 
     
         1 . A method for treating a subject suspected to having an aggressive prostate cancer, the method comprising:
 i. obtaining a blood sample from a subject having prostate cancer;   ii. isolating genomic DNA from the sample;   iii. detecting the presence of at least one alleles selected from the group consisting of: a G allele at the rs1714987 SNP in the ACACA gene, a G allele at the rs17275986 SNP in the SEMA3C gene, a G allele at the rs362708 SNP in the RELN gene, a G allele at the rs3817552 SNP in the MYBPC1 gene, an A allele at the rs8546 SNP in the NCOR2 gene, and a T allele at the rs11911090 SNP in the WDR4 gene; and   iv. administering to the subject at least one cancer therapy for the treatment of prostate cancer.   
     
     
         2 . The method of  claim 1 , wherein step (iii) comprises detecting the presence of at least two alleles. 
     
     
         3 . The method of  claim 1 , wherein the at least one allele comprise a G allele at the rs1714987 SNP in the ACACA gene. 
     
     
         4 . The method of  claim 1 , wherein the at least one alleles comprise a G allele at the rs17275986 SNP in the SEMA3C gene. 
     
     
         5 . The method of  claim 1 , wherein the at least one alleles comprise a G allele at the rs362708 SNP in the RELN gene. 
     
     
         6 . The method of  claim 1 , wherein the at least one alleles comprise a G allele at the rs3817552 SNP in the MYBPC1 gene. 
     
     
         7 . The method of  claim 1 , wherein the at least one alleles comprise an A allele at the rs8546 SNP in the NCOR2 gene. 
     
     
         8 . The method of  claim 1 , wherein the at least one alleles comprise a T allele at the rs11911090 SNP in the WDR4 gene. 
     
     
         9 . The method of  claim 1 , wherein step (c) of the method further comprises detecting the presence of an allele selected from a C allele at the rs2248490 SNP in the WDR4 gene and a G allele at the rs15736 SNP in the WDR4 gene. 
     
     
         10 . The method of  claim 1 , wherein the subject is African American. 
     
     
         11 . The method of  claim 1 , wherein the cancer therapy is selected from the group consisting of chemotherapy, hormone therapy, androgen therapy, radiation, surgery, vaccine therapy, immunotherapy, targeted therapy and combinations thereof.