Vacuum-controlled liquid delivery systems and methods for drawing a liquid into a syringe

Abstract

A vacuum controlled liquid delivery system, including a primary chamber; a manifold assembly affixed to the primary chamber, the manifold assembly comprising a feed line and an external pressure line; and a cap configured to reversibly engage the manifold assembly at one end and reversibly cap a syringe at another end, the cap comprising a septum and a porous plug, wherein when the cap is attached to the manifold assembly the feed line passes through the septum, and further wherein the porous plug seals upon contact with a liquid.

What is claimed is: 
     
         1 . A vacuum controlled liquid delivery system, comprising:
 a) a receiving chamber configured to house an expandable container during expansion, wherein the receiving chamber is also configured to seal air-tight;   b) a fitting train in fluid communication with a liquid feed line, wherein the fitting train regulates passage of liquid into the receiving chamber for delivery into a received container, the fitting train comprising a pair of detachable valves that selectively permit and prevent liquid delivery across the train when attached and when detached maintain a liquid-tight seal;   c) a vacuum pump; and   d) a set of control valves comprising:
 i) a feed valve that regulates liquid delivery to the fitting train, 
 ii) a chamber vacuum valve that regulates vacuum inside the chamber, and 
 iii) a feed line vacuum valve that regulates vacuum inside the feed line. 
   
     
     
         2 . The liquid delivery system of  claim 1 , wherein the chamber seals by way of a chamber door that closes against a gasket. 
     
     
         3 . The liquid delivery system of  claim 1 , wherein the expandable container is a syringe. 
     
     
         4 . The liquid delivery system of  claim 1 , wherein one of the valves within the pair of valves controls the opening and closing of both valves within the pair of valves. 
     
     
         5 . The liquid delivery system of  claim 1 , wherein one of the valves within the pair of detachable valves is selected from the group consisting of a luer valve, a spike valve, and a valve having a an inner housing configured for longitudinal movement in relation to an outer housing to open and close the valve. 
     
     
         6 . The liquid delivery system of  claim 5 , wherein the pair of valves comprise the luer valve and the valve having an inner housing configured for longitudinal movement in relation to an outer housing to open and close the valve. 
     
     
         7 . The liquid delivery system of  claim 1 , further comprising a vacuum meter configured to measure vacuum within the chamber and/or a vacuum meter configured to measure vacuum within the feed line. 
     
     
         8 . The liquid delivery system of  claim 1 , further comprising executable software loaded in a computer or downloadable to a computer that instructs opening and closing of the set of in-line valves to fill an expandable container with liquid. 
     
     
         9 . The liquid delivery system of  claim 1 , further comprising an expandable container reversibly mounted to the fitting train. 
     
     
         10 . A vacuum controlled liquid delivery system, comprising:
 a) a receiving chamber sized to house an expandable container during its expansion, the receiving chamber configured to seal air-tight;   b) a manifold assembly accessing an interior of the chamber, the manifold assembly comprising a feed line and a manifold vacuum line, wherein the feed line is configured to feed liquid, and the manifold vacuum line is functionally coupled to a vacuum pump to regulate a vacuum within the manifold assembly;   c) a cap configured to reversibly engage the manifold assembly to form an air-tight seal and configured to cap an expandable container, the cap comprising a septum and a porous plug, wherein when the cap is attached to the manifold assembly the feed line passes through the septum to permit passage of liquid and further wherein the porous plug seals upon contact with liquid.   
     
     
         11 . The liquid delivery system of  claim 10 , wherein pressure within receiving chamber is regulated by a chamber vacuum valve and a same or different vacuum pump. 
     
     
         12 . The system of  claim 10 , wherein the chamber comprises a barrier in alignment but spaced from the manifold assembly to limit expansion of an expanding container. 
     
     
         13 . The system of  claim 10 , wherein the feed line comprises a non-coring needle for passage through the septum. 
     
     
         14 . The system of  claim 10 , wherein the feed line comprises a feed valve that regulates the flow of liquid through the feed line. 
     
     
         15 . The system of  claim 10 , wherein when the cap is fully engaged the porous plug is exposed to an interior of the manifold assembly and an interior of the cap, thereby regulating communication between the interior of the manifold assembly and the interior of the cap. 
     
     
         16 . The system of  claim 10 , wherein the porous plug comprises an aperture and a swellable matrix that swells to seal the plug when contacting liquid. 
     
     
         17 . The system of  claim 16 , wherein the swellable matrix comprises sucrose or a hydrogel. 
     
     
         18 . A vacuum controlled liquid delivery method for filling a container, the method comprising:
 a) connecting the feed line of the system of  claim 1  to a feed tank comprising a liquid for delivery;   b) mounting a container to the fitting train so that the fitting train is in an open position;   c) forming an air-tight seal within the receiving chamber;   d) inducing a vacuum in the receiving chamber and in the feed line to position the container in a compressed state under vacuum forces;   e) opening the feed line to fill the expandable container with the liquid under the vacuum forces;   f) closing the feed line valve;   g) relieving the vacuum from the receiving chamber;   h) closing the pair of detachable valves; and   i) removing the container from the receiving chamber.   
     
     
         19 . The method of  claim 18 , wherein the container maintains one of the detachable valves when removed. 
     
     
         20 . A vacuum controlled liquid delivery method for filling a container, the method comprising:
 a) connecting the feed line of the system of  claim 1  to a feed tank comprising a liquid for delivery;   b) capping a collapsible container with the cap;   c) engaging the capped container with the manifold assembly such that an interior of the cap forms an air-tight seal with an interior of the manifold assembly, and the fluid line passes through the septum to fluidly access the container;   d) inducing a vacuum in the receiving chamber and in the manifold assembly to position the container in a compressed state under vacuum forces;   e) unsealing the fluid feed line to feed the liquid into the container under vacuum and against the porous plug, thereby sealing the plug;   f) resealing the feed line to obstruct flow through the feed line;   g) relieving the vacuum from the receiving chamber and the manifold assembly; and   h) disengaging the capped syringe from the manifold assembly.