Systems and methods for treating skin conditions with magnesium ion compositions

Abstract

The present disclosure provides for systems and methods including pre-moistened dressings with a treatment composition, wherein the dressings can include a water proof occlusive material on one side and an absorbing material for the treatment composition, thereby enabling direct contact transfer of the treatment composition to the skin surface. The treatment composition can include 2-70% wt/vol of a magnesium complex in water. The dressings can be replaced every one to three days for a total treatment time of one to 36 days or more. The treatment systems can be used to treat psoriasis and chronic inflammation, among others.

We claim: 
     
         1 . A treatment system for a psoriasis outbreak, the treatment system comprising:
 a composition including 20-70% wt/vol of a magnesium complex in water;   a medical dressing, wherein 1-6 mL the composition is applied one side of the medical dressing.   
     
     
         2 . The treatment system of  claim 1 , wherein the medical dressing includes
 an outer impermeable backing layer,   an inner polymeric layer dispersed with the magnesium composition, wherein the polymeric layer contacts the psoriasis outbreak, and   an adhesive surrounding the perimeter of the inner polymeric layer for adhering the medical dressing to a patient's body.   
     
     
         3 . The treatment system of  claim 2 , wherein the polymeric layer is a rate controlling polymer. 
     
     
         4 . The treatment system of  claim 1 , wherein the medical dressing includes
 an outer impermeable backing layer,   a drug reservoir for receiving the magnesium composition,   a rate controlling polymeric layer, wherein the polymeric layer contacts the psoriasis outbreak, wherein the polymeric layer is in liquid communication with the drug reservoir, and   an adhesive surrounding the perimeter of the polymeric layer for adhering the medical dressing to a patient's body.   
     
     
         5 . The treatment system of  claim 1 , wherein magnesium complex is magnesium chloride, magnesium sulfate, or combinations thereof. 
     
     
         6 . The treatment system of  claim 1 , wherein the composition includes 1.5-2.5 mL of a 55-60% wt/vol magnesium chloride. 
     
     
         7 . The treatment system of  claim 1 , wherein the composition includes 1.5-2.5 mL of a 20-60% wt/vol magnesium sulfate. 
     
     
         8 . A treatment method for an inflammatory disorder, the method comprising:
 providing a medical dressing impregnated 1-5 mL of 20-60% wt/vol of a magnesium complex;   applying the medical dressing to a treatment location; and   replacing the medical dressing after 8-48 hours.   
     
     
         9 . The method of  claim 8 , wherein the composition includes 700 mg of magnesium chloride in 5 mL of water. 
     
     
         10 . The method of  claim 8 , further comprising replacing the applied medical dressing with a new medical dressing every 24-48 hours for 10-40 days. 
     
     
         11 . The treatment method of  claim 8  further comprising
 after removing the medical dressing, applying an iontophoresis pad, wherein an active electrode of the iontophoresis pad is impregnated with 3-5 mL of 2-50% wt/vol of magnesium sulfate; and 
 administering a 70-90 mA dose at a positive setting of 1-3 mA for 1-4 hours. 
 
     
     
         12 . The treatment method of  claim 11 , wherein a surface of the active electrode includes a plurality of hollow needles to deliver the magnesium solution.