Endometriosis Classifier

Abstract

The present disclosure provides methods and compositions that are useful for diagnosing the presence or absence of endometriosis and the severity of endometriosis in a subject. The methods and compositions are also useful for distinguishing endometriosis from other uterine or pelvic pathologies in a subject. Also described are sets of genes whose expression levels in a biological sample are diagnostic for endometriosis, and compositions useful for diagnosis, prognosis, and/or treatment of endometriosis.

What is claimed is: 
     
         1 . A kit for diagnosing endometriosis, the kit comprising a plurality of oligonucleotides that specifically hybridize to mRNA, or a complement thereof, expressed by a set of genes, the set of genes comprising the genes in Table 7, Table 8, Table 9, Table 10, Table 11, Table 12, Table 13, Table 14, or Table 15, or any combination thereof. 
     
     
         2 . The kit of  claim 1 , where the oligonucleotides are selected from at least one specific probe set per gene in Table 7, Table 8, Table 9, Table 10, Table 11, Table 12, Table 13, Table 14, or Table 15. 
     
     
         3 . A kit for diagnosing the presence of endometriosis, the kit comprising a set of oligonucleotides that specifically hybridize to mRNA, or a complement thereof, expressed by the set of genes in Table 7, the set of genes in Table 8, the set of genes in Table 10, the set of genes in Table 11, the set of genes in Table 13, or the set of genes in Table 14. 
     
     
         4 . A kit for diagnosing the severity of endometriosis, the kit comprising a set of oligonucleotides that specifically hybridize to mRNA, or a complement thereof, expressed by the set of genes in Table 9 the set of genes in Table 12, or the set of genes in Table 15. 
     
     
         5 . A kit for diagnosing endometriosis comprising a set of probes for detecting nucleic acids or proteins expressed by a plurality of the genes in Tables 7-15. 
     
     
         6 . A microarray comprising a set of oligonucleotides that specifically hybridize to mRNA expressed by one or more sets of genes, the set of genes comprising the genes in Table 7, Table 8, Table 9, Table 10, Table 11, Table 12, Table 13, Table 14, or Table 15, or any combination thereof.