Broad Spectrum Antiviral and Methods of Use

Abstract

A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.

1 . A method of treating a virus infection in an individual in need thereof, comprising:
 administering to the individual an effective antiviral amount of a compound or a pharmaceutically acceptable salt or solvate thereof, wherein the compound is of Formula (I) or Formula (II)   
       
         
           
           
               
               
           
         
         wherein X is selected from the group consisting of —PO 3 H 2 , hydrogen, acetyl, isobutyryl, pivaloyl, and benzoyl, 
         wherein each of R 1 , R 2 , and R 3  is independently selected from hydrogen and C1-6 alkyl, 
         wherein n is an integer of from 1 to 10, and 
         wherein the virus is a DNA virus, an RNA virus, a DNA reverse transcribing virus or a non Retroviridae RNA reverse transcribing virus. 
       
     
     
         2 . The method of  claim 1 , wherein R 1  is methyl, R 2  is hydrogen, R 3  is hydrogen, n is 3, and X is —PO 3 H 2 . 
     
     
         3 . The method of  claim 1 , wherein R 1  is methyl, R 2  is hydrogen, R 3  is hydrogen, n is 3, and X is hydrogen. 
     
     
         4 . The method of  claim 1 , wherein R 1  is hydrogen, R 2  is hydrogen, R 3  is hydrogen, n is 3, and X is —PO 3 H 2 . 
     
     
         5 . The method of  claim 1 , wherein R 1  is hydrogen, R 2  is hydrogen, R 3  is hydrogen, n is 3, and X is hydrogen. 
     
     
         6 . The method of  claim 1 , wherein the compound is administered to the individual at a daily dosage of from about 200 mg/m 2  to about 3000 mg/m 2 . 
     
     
         7 . The method of  claim 1 , wherein the step of administering is selected from the group consisting of orally administering, intravenously administering, parenterally administering, subcutaneously administering, and administering by inhalation. 
     
     
         8 . A method of treating a virus infection in an individual in need thereof, comprising:
 administering to the individual an effective antiviral amount of:   (i) amifostine, the free thiol form of amifostine, the disulfide of amifostine (WR-33278), a combination of both the free thiol and the disulfide of amifostine, or other structurally and functionally related compounds; or   (ii) phosphonol, the free thiol form of phosphonol, the disulfide of phosphonol, a combination of both the free thiol and the disulfide of phosphonol, or other structurally and functionally related compounds,   wherein the virus is a DNA virus, an RNA virus, a DNA reverse transcribing virus, or a non Retroviridae RNA reverse transcribing virus.   
     
     
         9 . (canceled) 
     
     
         10 . The method of  claim 1 , wherein said
 administering comprises administering to the individual an effective antiviral amount of at least one compound selected from the group consisting of:   
       
         
           
           
               
               
           
         
       
     
     
         11 . The method of  claim 1 , wherein said
 administering comprises administering to the individual an effective antiviral amount of at least one compound selected from the group consisting of:   
       
         
           
           
               
               
           
         
       
     
     
         12 . A pharmaceutical kit comprising:
 a pharmaceutical composition comprising a compound or pharmaceutically acceptable salt or solvate thereof in a pharmaceutically acceptable carrier, the compound having Formula (I) or Formula (II):   
       
         
           
           
               
               
           
         
         wherein X is selected from the group consisting of —PO 3 H 2 , hydrogen, acetyl, isobutyryl, pivaloyl, and benzoyl, 
         wherein each of R 1 , R 2 , and R 3  is independently selected from hydrogen and C 1-6  alkyl, and 
         wherein n is an integer of from 1 to 10; and 
         directions for administering the pharmaceutical composition to a patient infected with a DNA virus, an RNA virus, a DNA reverse transcribing virus or a non Retroviridae RNA reverse transcribing virus. 
       
     
     
         13 . The method of  claim 1 , wherein the virus is a member of the Adenoviridae family or the Orthomyxoviridae family.