Preservative free brimonidine and timolol solutions

Abstract

The present invention is directed to preservative-free solutions of brimonidine and timolol for lowering intra-ocular pressure and treatment of glaucoma.

1 ) A preservative free brimonidine and timolol composition for lowering intraocular pressure in a human patient comprising the following formulation: about 0.2% w/v brimonidine; about 0.5% w/v timolol; about 2.15% w/v sodium phosphate dibasic heptahydrate; water and at a pH of about 6.9. 
     
     
         2 ) A preservative free brimonidine and timolol composition for lowering intraocular pressure in a human patient comprising the following formulation: 0.2% w/v brimonidine; 0.5% w/v timolol; about 2.15% w/v sodium phosphate dibasic heptahydrate; hydrochloric acid, sodium hydroxide, and water and at a pH of about 6.9. 
     
     
         3 ) The preservative free composition of  claim 1  wherein the timolol is timolol maleate at 0.68% w/v and brimonidine is brimonidine tartrate. 
     
     
         4 ) A composition as described in Table 1. 
     
     
         5 ) The composition of  claim 1  wherein the composition is a solution and is useful for treating glaucoma. 
     
     
         6 ) The composition of  claim 1  wherein the composition is a solution and is contained in a unit dose kit form. 
     
     
         7 ) The composition of  claim 1  wherein the composition is applied at least once a day. 
     
     
         8 ) The composition of  claim 2  wherein the composition is applied twice a day. 
     
     
         9 ) The composition of  claim 1  wherein the composition has greater bioavailability of brimonidine and timolol in the eye of the patient with fewer side-effects than brimonidine and timolol preserved with benzalkonium chloride. 
     
     
         10 ) A method of lowering IOP in a patient suffering from elevated IOP by administering the composition of  claim 1 .