US2021228479A1PendingUtilityA1

Steroidal compositions and method of making and use

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Assignee: FARMAKEIO NUTRACEUTICALS LLCPriority: Jan 29, 2020Filed: Jan 29, 2021Published: Jul 29, 2021
Est. expiryJan 29, 2040(~13.5 yrs left)· nominal 20-yr term from priority
Inventors:Cody BoatmanDaniel Deneui
A61K 9/2054A61K 9/0024A61K 9/282A61K 31/568A61K 31/573
55
PatentIndex Score
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Claims

Abstract

Disclosed herein are compositions suitable for use in increasing the energy level, memory function and cognitive focus, and lowering the feeling of lethargy in men and women. Further disclosed are methods of use and processes for preparing the disclosed compositions.

Claims

exact text as granted — not AI-modified
1 . An implantable pharmaceutical composition, comprising:
 a) from about 90% to about 99% by weight of testosterone:   b) from about 0.005% to about 0.05% by weight of triamcinolone; and   c) the balance carriers and adjunct ingredients;   wherein the composition is in the form of a pellet having a hardness of at less than about 75 Newtons.   
     
     
         2 . The composition according to  claim 1 , wherein the composition comprises from about 92% to about 99% by weight of testosterone. 
     
     
         3 . The composition according to  claim 1 , wherein the composition comprises from about 90% to about 97% by weight of testosterone. 
     
     
         4 . The composition according to  claim 1 , wherein the composition comprises from about 93% to about 99% by weight of testosterone. 
     
     
         5 . The composition according to  claim 1 , wherein the composition comprises from about 90% to about 96% by weight of testosterone. 
     
     
         6 . The composition according to  claim 1 , wherein the composition comprises from about 93% to about 97% by weight of testosterone. 
     
     
         7 . The composition according to  claim 1 , wherein the composition comprises 95% by weight of testosterone. 
     
     
         8 . The composition according to  claim 1 , wherein the composition comprises from about 0.0075% to about 0.05% by weight of triamcinolone. 
     
     
         9 . The composition according to  claim 1 , wherein the composition comprises from about 0.005% to about 0.04% by weight of triamcinolone. 
     
     
         10 . The composition according to  claim 1 , wherein the composition comprises from about 0.01% to about 0.04% by weight of triamcinolone. 
     
     
         11 . The composition according to  claim 1 , wherein the composition comprises from about 0.015% to about 00.3% by weight of triamcinolone. 
     
     
         12 . The composition according to  claim 1 , wherein the composition comprises 0.02% by weight of triamcinolone. 
     
     
         13 . The composition according to  claim 1 , comprising about 4% by weight of a coating agent. 
     
     
         14 . The composition according to  claim 13 , wherein the coating agent is chose from dextran, poly(ε-caprolactone), poly(1,4-dioxan-2-one), poly(sebacic anhydride), poly(dodecanoic anhydride), poly(ethylene glycol), polyoxyethylene, stearic acid, stearyl alcohol, ethylene glycol palmitostearate, cetyl esters wax, poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) or a combination thereof. 
     
     
         15 . The composition according to  claim 13 , wherein the coating agent is stearic acid or stearyl alcohol. 
     
     
         16 . The composition according to  claim 13 , wherein the coating agent is stearic acid. 
     
     
         17 . The composition according to  claim 1 , further comprising a binding agent. 
     
     
         18 . The composition according to  claim 17 , wherein the binding agent is chosen from polyethylene glycol 1500, polyethylene glycol 2000, polyethylene glycol 3000, polyethylene glycol 4000, polyethylene glycol 6000, polyethylene glycol 8000, polyethylene glycol 10000, methylcellulose, ethylcellulose, hydroxymethyl cellulose, hydroxyethylcellulose, hydroxypropyl methylcellulose, polyoxyethylene, copolymers of polyoxyethylene-polyoxypropylene and mixtures thereof. 
     
     
         19 . The composition according to  claim 18 , wherein the binding agent is methylcellulose, ethylcellulose, hydroxymethyl cellulose, or hydroxyethylcellulose. 
     
     
         20 . The composition according to  claim 18 , wherein the binding agent is ethylcellulose. 
     
     
         21 .- 55 . (canceled)

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