Combined stent reperfusion system

Abstract

Devices and methods for preventing reperfusion injuries when an occlusion balloon is deflated. A catheter having an infusion lumen exiting the catheter distal of a stent balloon and/or occlusion balloon allows a therapeutic agent to be introduced to a target location to establish desired temperatures and pressures prior to deflation of the balloon such that negative effects of reperfusion are minimized.

1 . A combined stent delivery and occlusion device comprising:
 a proximal manifold including:
 an infusion port; and 
 a stent balloon inflation port; 
   a catheter extending distally from the manifold and defining an infusion lumen in fluid communication with the infusion port, and an inflation lumen in fluid communication with the stent balloon inflation port;   a therapeutic agent port in fluid communication with a therapeutic agent lumen further defined by the catheter and leading to a distal end of the catheter;   a stent balloon near the distal end of the catheter and surrounding the catheter, the stent balloon in fluid communication with the inflation lumen; and   a stent surrounding the stent balloon.   
     
     
         2 . The combined stent delivery and occlusion device of  claim 1 , wherein the stent balloon, when inflated, serves as an occlusion balloon, blocking blood flow through a vessel in which the stent balloon is inflated. 
     
     
         3 . The combined stent delivery and occlusion device of  claim 1 , wherein the therapeutic agent port is located distal of the manifold. 
     
     
         4 . The combined stent delivery and occlusion device of  claim 1 , further comprising an occlusion balloon. 
     
     
         5 . The combined stent delivery and occlusion device of  claim 4 , wherein the occlusion balloon is located distal of the stent balloon. 
     
     
         6 . The combined stent delivery and occlusion device of  claim 4 , wherein the proximal manifold further includes an occlusion balloon inflation port. 
     
     
         7 . The combined stent delivery and occlusion device of  claim 6 , wherein the catheter further defines an occlusion balloon inflation lumen. 
     
     
         8 - 16 . (canceled) 
     
     
         17 . The combined stent delivery and occlusion device of  claim 4 , wherein the occlusion balloon is located proximal of the stent balloon. 
     
     
         18 . The combined stent delivery and occlusion device of  claim 4 , wherein the occlusion balloon has different properties than the stent balloon. 
     
     
         19 . The combined stent delivery and occlusion device of  claim 4 , wherein the infusion lumen is configured to accommodate a rapid exchange guidewire. 
     
     
         20 . A combined stent delivery and occlusion system comprising:
 a proximal manifold including:
 an infusion port; 
 a stent balloon inflation port; and 
 an occlusion balloon inflation port; 
   a catheter extending distally from the manifold and defining an infusion lumen in fluid communication with the infusion port, a stent balloon inflation lumen in fluid communication with the stent balloon inflation port, and an occlusion balloon inflation lumen in fluid communication with the occlusion balloon inflation port;   a guidewire having one or more sensors;   a stent balloon near a distal end of the catheter and surrounding the catheter, the stent balloon in fluid communication with the stent balloon inflation lumen;   a stent surrounding the stent balloon; and   an occlusion balloon near the distal end of the catheter and surrounding the catheter, the occlusion balloon in fluid communication with the occlusion balloon inflation lumen;   wherein the infusion lumen is configured to accommodate the guidewire.   
     
     
         21 . The combined stent delivery and occlusion system of  claim 20 , further comprising a therapeutic agent port in fluid communication with a therapeutic agent lumen further defined by the catheter and leading to the distal end of the catheter. 
     
     
         22 . The combined stent delivery and occlusion system of  claim 21 , wherein the occlusion balloon and the stent balloon are fixed relative to a longitudinal direction of the catheter. 
     
     
         23 . The combined stent delivery and occlusion system of  claim 21 , wherein the occlusion balloon is located distal of the stent balloon. 
     
     
         24 . The combined stent delivery and occlusion system of  claim 21 , wherein the occlusion balloon has different properties than the stent balloon. 
     
     
         25 . A combined stent delivery and occlusion system comprising:
 a proximal manifold including:
 an infusion port; 
 a stent balloon inflation port; and 
 an occlusion balloon inflation port; 
   a catheter extending distally from the manifold and defining an infusion lumen in fluid communication with the infusion port, a stent balloon inflation lumen in fluid communication with the stent balloon inflation port, and an occlusion balloon inflation lumen in fluid communication with the occlusion balloon inflation port;   measurement technology mounted on the catheter;   a stent balloon near a distal end of the catheter and surrounding the catheter, the stent balloon in fluid communication with the stent balloon inflation lumen;   a stent surrounding the stent balloon; and   an occlusion balloon near the distal end of the catheter and surrounding the catheter, the occlusion balloon in fluid communication with the occlusion balloon inflation lumen.   
     
     
         26 . The combined stent delivery and occlusion system of  claim 25 , further comprising a therapeutic agent port in fluid communication with a therapeutic agent lumen further defined by the catheter and leading to the distal end of the catheter. 
     
     
         27 . The combined stent delivery and occlusion system of  claim 26 , wherein the infusion lumen is configured to accommodate a rapid exchange guidewire 
     
     
         28 . The combined stent delivery and occlusion system of  claim 27 , wherein the occlusion balloon is located distal of the stent balloon. 
     
     
         29 . The combined stent delivery and occlusion system of  claim 27 , wherein the occlusion balloon has different properties than the stent balloon.