Amorphous forms of selinexor and process for their preparation

Abstract

Aspects of the present application relate to solid forms of Selinexor, processes for their preparation and pharmaceutical compositions thereof. Specific aspects relate to crystalline and amorphous forms of Selinexor.

1 - 45 . (canceled) 
     
     
         46 - 74 . (canceled) 
     
     
         75 . An amorphous form of Selinexor. 
     
     
         76 . A process for preparing the amorphous form of Selinexor of  claim 75 , comprising the steps of:
 a) providing a solution of Selinexor in a solvent or a mixture thereof;   b) removing the solvent from the solution obtained in step a);   c) isolating the amorphous form of Selinexor; and   d) optionally combining amorphous form of step c) with at least one pharmaceutically acceptable excipient.   
     
     
         77 . An amorphous solid dispersion of Selinexor together with at least one pharmaceutically acceptable excipient. 
     
     
         78 . A process for preparing the amorphous solid dispersion of Selinexor of  claim 77 , comprising the steps of:
 a) providing a solution of Selinexor and at least one pharmaceutically acceptable excipient in a solvent or a mixture thereof;   b) removing the solvent from the solution obtained in step a),   c) isolating the amorphous solid dispersion of Selinexor; and   d) optionally combining amorphous solid dispersion of step c) with at least one additional pharmaceutically acceptable excipient.   
     
     
         79 . (canceled) 
     
     
         80 . A pharmaceutical composition comprising the amorphous form of Selinexor of  claim 75  combined with at least one pharmaceutically acceptable excipient. 
     
     
         81 . A pharmaceutical composition comprising the amorphous solid dispersion of Selinexor of  claim 77  combined with at least one additional pharmaceutically acceptable excipient. 
     
     
         82 . (canceled)