Nitrated-fatty acids modulation of type ii diabetes

Abstract

Nitro oleic acid and related metabolites are agonists of PPAR-γ. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-γ, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therapeutics for the treatment of type-2 diabetes, which results from insulin resistance accompanying the improper functioning of PPAR-γ.

1 - 7 . (canceled) 
     
     
         8 . A method comprising modulating peroxisome proliferator activating receptor gamma (PPAR-γ) activity in a subject in need thereof, wherein the method comprises administering a nitro oleic acid, or a metabolite thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, to the subject. 
     
     
         9 . The method of  claim 8 , wherein the nitro oleic acid, the metabolite, the pharmaceutically acceptable salt, or the prodrug, activates (PPAR-γ) activity in the subject. 
     
     
         10 . The method of  claim 8 , wherein nitro oleic acid, or pharmaceutically acceptable salt thereof, or a prodrug thereof, is administered to the subject. 
     
     
         11 . The method of  claim 8 , wherein the nitro oleic acid, the metabolite, pharmaceutically acceptable salt, or the prodrug is included in a pharmaceutical composition. 
     
     
         12 . The method of  claim 8 , wherein the subject is a human. 
     
     
         13 . The method of  claim 10 , wherein the nitro oleic acid is 10-nitro-octadecenoic acid. 
     
     
         14 . The method of  claim 10 , wherein the nitro oleic acid is 9-nitro-octadecenoic acid. 
     
     
         15 . The method of  claim 9 , wherein nitro oleic acid, or pharmaceutically acceptable salt thereof, or a prodrug thereof, is administered to the subject. 
     
     
         16 . The method of  claim 10 , wherein the subject is a human. 
     
     
         17 . The method of  claim 15 , wherein the nitro oleic acid is 10-nitro-octadecenoic acid. 
     
     
         18 . The method of  claim 15 , wherein the nitro oleic acid is 9-nitro-octadecenoic acid.