Method to personalize a biomarker signal and medical procedures using the same

Abstract

The present invention relates to a method of enhancing the detection of a signal from biomarker data in a subject or group of subjects.

1 . A method of enhancing the detection and the personalization of a signal from biomarker data presenting significantly lower within- than between-subject biological variations in a subject or group of subjects comprising the steps of
 i) measuring one or more values of one or more previously selected biomarkers M from said subject or group of subjects, wherein said biomarkers M is/are indicator of a disease or of a physiological condition,   ii) defining stratified distributions of expected values for each biomarker M according to heterogeneous factors in said subject or group of subjects,   iii) applying an adaptive Bayesian model on the one or more values measured for the one or more markers of step i) to move from said stratified distributions to posterior individual distributions of expected values for each biomarker M in said subject or group of subjects,   iv) deriving from said individual distributions some individual reference Z scores and/or individual reference ranges for a given specificity level for each biomarker M,   v) measuring one or more additional values for one or more biomarkers M in said subject or group of subjects,   vi) comparing said one or more measured values to said individual reference ranges, and/or comparing the Z-score derived from said one or more measured values to said individual reference Z scores,   wherein a deviation of said one or more measured values from said one or more ranges, and/or deviation from said Z scores derived from said one or more measured values from said individual reference Z-scores, is indicative of said biological or physiological condition or variation in said subject or group of subjects.   
     
     
         2 . The method of enhancing the detection and the personalization of a signal from biomarker data in a subject or group of subjects of  claim 1 , wherein the one or more biomarkers M are phenotypic biomarkers. 
     
     
         3 . An apparatus for implementing the method of any one of  claims 1  to  2  selected from the group comprising a computer, a smartphone, a tablet and an internet server. 
     
     
         4 . Use of the method of  claim 1  or  2 , or the apparatus of  claim 3 , for inferring genetic polymorphisms from the measurement of one or more phenotypic biomarkers M associated with said genetic polymorphisms in a single individual, comprising the steps of
 i) measuring one or more values of one or more phenotypic biomarkers M from said subject, and 
 ii) comparing said one or more measured values to said one or more individual reference Z score and individual reference ranges, 
 wherein a deviation of said one or more measured values from said one or more individual reference Z scores and ranges is indicative of genetic information known to affect said one or more phenotypic biomarkers M in said subject or group of subjects.