Methods and kits for diagnosing, assessing or quantitatingdrug use, drug abuse and narcosis, Ν - ternuclear ophthalmoplegia, attention deficit hyperactivity disorder (adhd), chronic traumaticenceph alopathy,schizophrenia spectrum disorders and alcohol consumption

Abstract

A method for diagnosing, assessing or quantitating drug use, drug abuse or narcosis in a subject includes tracking eye pupil movement of at least one of a first eye and a second eye of the subject using a device suitable for tracking eye pupil movement, analyzing eye pupil movement of the at least one of the first eye and the second eye of the subject using a computer in electronic communication with the device suitable for tracking eye pupil movement, generating a plot that reflects a trajectory traveled of each of the at least one of the first eye and the second eye in response to a visual stimuli, comparing eye pupil movement of the at least one of the first eye and the second eye of the subject to a normal or mean eye pupil movement, and calculating a plurality of velocities.

1 - 107 . (canceled) 
     
     
         108 . A method for diagnosing, assessing or quantitating drug use, drug abuse or narcosis in a subject comprising:
 a) tracking eye pupil movement of at least one of a first eye and a second eye of the subject using a device suitable for tracking eye pupil movement;   b) analyzing eye pupil movement of the at least one of the first eye and the second eye of the subject using a computer in electronic communication with the device suitable for tracking eye pupil movement;   c) generating a plot that reflects a trajectory traveled of each of the at least one of the first eye and the second eye in response to a visual stimuli, the plot having four segments that represent different directions;   d) comparing eye pupil movement of the at least one of the first eye and the second eye of the subject to a normal or mean eye pupil movement; and   e) calculating a plurality of velocities including a segment velocity of eye pupil movement in each of the four segments of the plot, and comparing a first segment velocity of eye pupil movement with other segment velocities of the four segments.   
     
     
         109 . The method according to  claim 108  wherein eye pupil movement of the first eye and the second eye of the subject are tracked and analyzed. 
     
     
         110 . The method according to  claim 108  wherein both x and y coordinates of eye position for the first eye and the second eye of the subject are collected. 
     
     
         111 . The method according to  claim 109  wherein the eye pupil movement is tracked for at least about 100 or more seconds. 
     
     
         112 . The method according to  claim 108  wherein the tracking, analyzing and comparing comprises collecting raw x and y Cartesian coordinates of pupil position, normalizing the raw x and y Cartesian coordinates, and sorting data by eye. 
     
     
         113 . The method according to  claim 108  wherein the analyzing and comparing comprises calculating velocity of the eye pupil movement. 
     
     
         114 . The method according to  claim 112  wherein the x and y Cartesian coordinates of pupil position represent two components of an instantaneous angle of pupil reflection. 
     
     
         115 . The method according to  claim 108  wherein the comparing eye pupil movement of at least one of the first eye and the second eye of the subject to a normal or mean eye pupil movement comprises comparing eye pupil movement of at least one of the first eye and the second eye of the subject to the eye pupil movement of an eye of one or more other subjects or controls. 
     
     
         116 . The method according to  claim 108 , further comprising the step of determining the presence of drug use, drug abuse or narcosis in the subject if the segment velocity in one of the four segments is less than a segment velocity in others of the four segments. 
     
     
         117 . The method according to  claim 108  wherein the comparing further comprises comparing the segment velocity of eye pupil movement in each of the four segments to control velocities for each of the four segments. 
     
     
         118 . The method according to  claim 108 , further comprising the step of determining the presence of drug use, drug abuse or narcosis in the subject based on the shape of the plot. 
     
     
         119 . The method according to  claim 108 , wherein comparing a first segment velocity of eye pupil movement with other segment velocities of the four segments includes comparing segment velocities of the first eye pupil to other segment velocities of the first eye pupil. 
     
     
         120 . The method according to  claim 108 , further comprising the step of temporally calibrating pupil movement by predicting positions of the eye pupil based on time elapsed since a start of the visual stimuli.