Analyte sensing layers, analyte sensors and methods for fabricating the same

Abstract

Analyte sensors and methods for fabricating analyte sensors and analyte sensing layers are presented here. In accordance with certain embodiments, a method for fabricating an analyte sensor includes providing a base layer and forming a conductive layer over the base layer. Further, the method includes forming an analyte sensing layer disposed over the conductive layer. The analyte sensing layer includes glucose oxidase entrapped within a thermally-cured polymer matrix and within a UV-cured polymer matrix.

1 . An analyte sensor comprising:
 a base layer;   a conductive layer over the base layer; and   an analyte sensing layer disposed over the conductive layer, wherein the analyte sensing layer comprises glucose oxidase entrapped within a thermally-cured polymer matrix and a UV cured polymer matrix.   
     
     
         2 . The analyte sensor of  claim 1 , wherein the analyte sensor consists essentially of:
 a base layer;   a conductive layer over the base layer; and   an analyte sensing layer disposed over the conductive layer, wherein the analyte sensing layer comprises glucose oxidase entrapped within a thermally-cured polymer matrix and a UV cured polymer matrix.   
     
     
         3 . The analyte sensor of  claim 1 , wherein the analyte sensing layer functions as a glucose limiting material that regulates the amount of glucose that contacts the glucose oxidase. 
     
     
         4 . The analyte sensor of  claim 1 , wherein the analyte sensing layer is not coated with one or more additional layers. 
     
     
         5 . The analyte sensor of  claim 1 , wherein a combination of materials comprising the base layer, the conductive layer and the analyte sensing layer is not disposed next to one or more additional layers. 
     
     
         6 . The analyte sensor of  claim 2 , wherein the analyte sensing layer comprises a glucose limiting material that regulates the amount of glucose that contacts the glucose oxidase. 
     
     
         7 . The analyte sensor of  claim 3 , wherein polymeric materials disposed over the conductive layer in the analyte sensor are less than 100 microns in thickness. 
     
     
         8 . The analyte sensor of  claim 6 , wherein the glucose sensing and glucose limiting layer disposed over the conductive layer in the analyte sensor is less than 100 microns in thickness. 
     
     
         9 . The analyte sensor of  claim 6 , wherein the analyte sensing layer comprises thermally crosslinked moieties. 
     
     
         10 . An analyte sensor comprising:
 a base layer;   a conductive layer over the base layer; and   an analyte sensing layer disposed over the conductive layer, wherein:   the analyte sensing layer comprises glucose oxidase entrapped within a thermally-cured polymer matrix and a UV cured polymer matrix;   the analyte sensing layer functions as a glucose limiting material that regulates the amount of glucose that contacts the glucose oxidase; and   the analyte sensing layer is not coated with one or more additional layers.   
     
     
         11 . The analyte sensor of  claim 10 , wherein polymeric materials disposed over the conductive layer in the analyte sensor are less than 100 microns in thickness. 
     
     
         12 . The analyte sensor of  claim 10 , wherein the analyte sensing layer comprises thermally crosslinked moieties. 
     
     
         13 . The analyte sensor of  claim 12 , wherein the analyte sensing layer comprises a UV-cured monomer or oligomer. 
     
     
         14 . The analyte sensor of  claim 13 , wherein the UV-cured monomer or oligomer comprises an acrylate. 
     
     
         15 . An analyte sensor comprising:
 a base layer;   a conductive layer over the base layer; and   an analyte sensing layer disposed over the conductive layer, wherein:   the analyte sensing layer comprises glucose oxidase entrapped within a thermally-cured polymer matrix and a UV cured polymer matrix;   the analyte sensing layer comprises a glucose limiting material that regulates the amount of glucose that contacts the glucose oxidase; and   the analyte sensing layer is not disposed next to one or more additional layers selected from:   a protein layer;   an analyte modulating layer;   an adhesion promoting layer; and   an interference rejection layer.   
     
     
         16 . The analyte sensor of  claim 15 , wherein polymeric materials disposed over the conductive layer in the analyte sensor are less than 100 microns in thickness. 
     
     
         17 . The analyte sensor of  claim 16 , wherein polymeric materials disposed over the conductive layer in the analyte sensor are less than 50 microns in thickness. 
     
     
         18 . The analyte sensor of  claim 15 , wherein the analyte sensing layer comprises thermally crosslinked moieties. 
     
     
         19 . The analyte sensor of  claim 18 , wherein the analyte sensing layer comprises a UV-cured monomer or oligomer. 
     
     
         20 . The analyte sensor of  claim 19 , wherein the UV-cured monomer or oligomer comprises an acrylate.